中国现代医生2025，Vol.63Issue(15)：19-24,6.DOI:10.3969/j.issn.1673-9701.2025.15.005
血清铁蛋白与青少年代谢相关脂肪性肝病的相关性
The relationship between serum ferritin and metabolic associated fatty liver disease in adolescents
摘要
Abstract
Objective To investigate the relationship between serum ferritin(SF)and metabolic associated fatty liver disease(MAFLD)in adolescents.Methods This study utilized data from 2017 to 2020 national health and nutrition examination survey database,ultimately including 559 adolescents aged 12～18 years,divided into MAFLD group(119 cases)and non-MAFLD group(440 cases).Data on demographic characteristics,serum iron metabolism indicators,liver function,lipid profiles,glucose levels,and other relevant parameters were collected.Liver steatosis and fibrosis were assessed using vibration-controlled transient elastography.Pearson correlation and Logistic regression analyses were performed to evaluate the relationship between SF and MAFLD.Results SF levels were significantly higher in MAFLD group compared to non-MAFLD group(P<0.05).Pearson correlation analysis indicated that SF was positively correlated with the controlled attenuation parameter,liver stiffness measurement,body mass index(BMI),alanine aminotransferase(ALT),γ-glutamyl transferase,triglycerides,and uric acid levels(P<0.05),but negatively correlated with high-density lipoprotein cholesterol levels(P<0.05).Adolescents were divided into 4 groups according to the quartiles of SF levels(Q1 goup:SF 1.9-25.6ng/ml;Q2 goup:SF 25.7-41.7ng/ml;Q3 goup:SF 41.8-70.4ng/ml;Q4 goup:SF 70.5-445.0ng/ml).The results of Logistic regression analysis showed that when the variables were not adjusted,the risk of MAFLD in Q4 group adolescents was significantly increased,this association disappeared after adjusting for gender,age,race,BMI,and other factors.BMI(OR=1.250,95％CI:1.176-1.329),globulin(OR=2.991,95％CI:1.218-7.343),ALT(OR=1.052,95％CI:1.003-1.104),and white blood cell count(OR=1.225,95％CI:1.041-1.441)were identified as independent risk factors for MAFLD.Conclusion SF levels are significantly elevated in adolescents with MAFLD but are not independently associated with the occurrence of MAFLD.BMI,globulin,ALT,and white blood cell count are important risk factors for adolescent MAFLD.关键词
代谢相关脂肪性肝病/血清铁蛋白/青少年Key words
Metabolic associated fatty liver disease/Serum ferritin/Adolescents分类
临床医学引用本文复制引用
刘萌萌,李雪,费悦,徐霞红..血清铁蛋白与青少年代谢相关脂肪性肝病的相关性[J].中国现代医生,2025,63(15):19-24,6.基金项目
上海市浦东新区公利医院青年基金项目(2024YQNJJ-28) （2024YQNJJ-28）
上海市浦东新区卫生系统重要薄弱学科建设资助项目(PWZbr2022-15) （PWZbr2022-15）
