摘要
Abstract
Objective To analyze the relationship between gut microbiota and breast cancer based on Mendelian randomization(MR).Methods The summary data of breast cancer and gut microbiota were downloaded from the GWAS catalog database and MiBioGen alliance,and inverse variance weighted(IVW)method was taken as the main statistical method,and MR-Egger(ME),weighted median(WME),weighted mode(WMO),and simple mode(SM)were taken as supplementary methods.MR analysis was used to explore the causal relationship between gut microbiota and breast cancer risk.Sensitivity analysis was used to test whether the results of MR were reliable.Results The results based on IVW showed that Flavonifractor(OR=1.00468,95％CI:1.00144-1.00793,P=0.005),Barnesiella(OR=1.00271,95％CI:1.00016-1.00526,P=0.037),Coprococcus1(OR=1.00316,95％CI:1.00034-1.00599,P=0.028)were positively correlated with breast cancer.Bacteroides(OR=0.99650,95％CI:0.99311-0.99991,P=0.0447),ErysipelotrichaceaeUCG003(OR=0.99577,95％CI:0.99331-0.99824,P=0.044).Ruminiclostridium9(OR=0.99684 95％CI:0.99378-0.99991,P=0.044),Prevotella7(OR=0.99798,95％CI:0.99641-0.99956,P=0.012)were negatively associated with breast cancer.Conclusion The causal relationship between gut microbiota and breast cancer was evaluated by MR analysis,and found that Flavonifractor,Barnesia,and Coprococcus were risk factors for breast cancer,but Bacteroides,Erysipelothriaceae,Ruminiclostridium and Prevotella were protective factors for breast cancer.关键词
乳腺癌/肠道微生物/孟德尔随机化Key words
Breast cancer/Gut microbiota/Mendelian randomization分类
临床医学
