中国现代医生2025，Vol.63Issue(15)：42-46,5.DOI:10.3969/j.issn.1673-9701.2025.15.009
高频重复经颅磁刺激对青少年抑郁症患者脑电活动的影响
The effect of high-frequency repeated transcranial magnetic stimulation on electroencephalogram in adolescent depression
范月圆 1唐斐 2晏克文 3李彦芳 2李娜1
作者信息
- 1. 昆明医科大学第一附属医院精神科,云南 昆明 650032
- 2. 曲靖市第三人民医院心身疾病科,云南 曲靖 655099
- 3. 昆明市妇幼保健院临床心理科,云南 昆明 650031
- 折叠
摘要
Abstract
Objective To study the effectiveness of combining antidepressant drug with high-frequency repeated transcranial magnetic stimulation(rTMS)in treating adolescent depression and explore its impact on electroencephalogram.Methods 60 cases of adolescent depression,who admitted to Department of Psychiatry,the First Affiliated Hospital of Kunming Medical University from September to December 2024 were selected and randomly divided into control group and observation group,with 30 cases in each group.Patients of control group were treated with selective serotonin reuptake inhibitor(SSRI),while patients of observation group received the same SSRI treatment in addition to high-frequency rTMS.The treatment lasted for 2 weeks.Both groups were assessed by using 24-item Hamilton depression rating scale(HAMD-24)and depression self-rating scale for children(DSRSC)before the start of treatment and at the end of two weeks of treatment.Adverse reactions were recorded throughout the treatment,and electroencephalogram monitoring was taken before and after treatment.Results Observation group showed a significantly higher treatment response rate compared to control group(P<0.05).After two weeks of treatment,HAMD-24 and DSRSC scores in observation group were notably lower than those in control group(P<0.01).Both groups exhibited improvements in brain wave power(δ,θ,α,β)after treatment(P<0.05),with observation group demonstrating superior β wave power compared to control group(P<0.01).Additionally,a negative correlation was found between α and β wave power in the left frontal region and DSRSC scores in observation group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between two groups(P>0.05).Conclusion Compared with SSRI treatment,rTMS combined with SSRI treatment can more effectively improve depressive symptoms,increase α and β brainwave power,and the combination therapy does not increase the incidence of adverse reactions,demonstrating good safety.关键词
高频重复经颅磁刺激/青少年抑郁症/脑电图Key words
High-frequency repeated transcranial magnetic stimulation/Adolescent depression/Electroencephalogram分类
临床医学引用本文复制引用
范月圆,唐斐,晏克文,李彦芳,李娜..高频重复经颅磁刺激对青少年抑郁症患者脑电活动的影响[J].中国现代医生,2025,63(15):42-46,5.
