中华耳科学杂志2025，Vol.23Issue(3)：379-383,5.DOI:10.3969/j.issn.1672-2922.2025.03.005
基于孟德尔随机化探索胃食管反流病与梅尼埃病的因果关联
Exploring the Causal Association Between Gastroesophageal Reflux Disease(GERD)and Meniere's Disease Using Mendelian Randomization
摘要
Abstract
Objective Previous studies have shown that Ménière's disease is often accompanied by gastroesophageal reflux disease(GERD).This study aims to assess the potential causal relationship using a two-sample Mendelian randomization(MR).Methods In March 2024,the IEU OpenGWAS platform was searched for genome-wide association studies(GWAS).Single nucleotide polymorphisms(SNPs)strongly associated with GERD were used as instrumental variables(IVs).Five regression models,namely inverse variance weighted(IVW),weighted median(WM),MR-Egger regression,weighted mode,and simple model,were employed to conduct MR analysis on the causal association between GERD and Meniere's disease.Sensitivity analyses were performed using Cochran's Q test,MR Egger intercept test,leave-one-out analysis,and funnel plot.Results IVs indicated increased the risk for Meniere's disease with GERD(OR=1.702,95%CI=1.106-2.618,P=0.01).WM showed similar results(OR=2.205,95%CI=1.214-4.006,P=0.009).Cochran's Q test and funnel plot suggested no heterogeneity among the IVs.MR-Egger intercept test indicated no horizontal pleiotropy in the IVs.Leave-one-out analysis showed that no individual SNP significantly influenced the overall results.Conclusion GERD significantly increases the risk for Meniere's disease.This study provides theoretical evidence for identifying risk factors associated with Meniere's disease.关键词
梅尼埃病/胃食管反流病/孟德尔随机化Key words
Meniere's disease/gastroesophageal reflux disease/Mendelian randomization引用本文复制引用
鲜印,田洪旭,杨智,冉玲潇,淳美玲,蒋双全..基于孟德尔随机化探索胃食管反流病与梅尼埃病的因果关联[J].中华耳科学杂志,2025,23(3):379-383,5.基金项目
南充市应用基础研究项目(22YYJCYJ0054) （22YYJCYJ0054）
四川省科技厅科技创新基地(平台)和人才计划(2023JDRC0091) （平台）
