摘要
Abstract
Objective To construct and validate the risk model of cognitive frailty in elderly patients with type 2 diabetes.Methods A total of 308 elderly patients with type 2 diabetes admitted to the Second Affiliated Hospital of Nanjing Medical University from January 2022 to January 2024 were included in the training set(215 cases)and the validation set(93 cases)with a ratio of 7∶3 by simple random sampling.Combining the Fried Frailty Phenotype(FFP)and the Montreal Cognitive Assessment(MoCA)to evaluate the occurrence of cognitive frailty in patients in the training and validation sets,patients with cognitive frailty in the training set were included in the occurrence group,otherwise they were included in the non-occurrence group.The general data of the two groups were compared.Logistic multi factor regression model was used to summarize the risk factors affecting cognitive frailty of elderly patients with type 2 diabetes,and a Nomogram risk model was established based on the risk factors.The Nomogram risk model was substituted into the validation set,and the receiver operating characteristic(ROC)curve was used to evaluate the effectiveness of the risk model application and calculate the area under the curve(AUC).Results There were 65 patients in the training set group experienced cognitive frailty,with an incidence rate of 30.23%(65/215).There were 26 patients in the validation set group who experienced cognitive frailty,with an incidence rate of 27.96%(26/93).The total incidence of cognitive frailty in 308 patients was 29.55%(91/308).Logistic multi factor regression model showed that albumin<30.0 g/L,fasting blood glucose≥7.0 mmol/L,glycosylated hemoglobin≥7.0%,living alone,having nutritional risk,and physical labor were all independent risk factors for cognitive frailty in elderly patients with type 2 diabetes(P<0.05).The AUC of the Nomogram prediction model based on risk factors applied to the training set and validation set were 0.877 and 0.816,respectively.Conclusion The incidence of cognitive frailty in elderly patients with type 2 diabetes is high,which is closely related to nutrition,living status,blood glucose control,and occupational conditions.The risk model based on the above factors can provide reliable reference for the risk assessment of cognitive frailty in patients.关键词
2型糖尿病/认知衰弱/老年/风险模型Key words
type 2 diabetes/cognitive frailty/old age/risk model分类
医药卫生
