北京中医药大学学报2025，Vol.48Issue(5)：605-612,8.DOI:10.3969/j.issn.1006-2157.2025.05.003
麝香通心滴丸改善冠状动脉慢血流即刻及短期疗效的临床研究
Clinical study on the immediate and short-term therapeutic effects of Shexiang Tongxin Dripping Pill on improving coronary slow flow
摘要
Abstract
Objective To explore the immediate and short-term effects of Shexiang Tongxin Dripping Pill in the intervention of coronary slow flow(CSF).Methods Through Interactive Web Response System,Sixty-four patients with CSF from Dongzhimen Hospital,Beijing University of Chinese Medicine were divided into a Shexiang Tongxin Dripping Pill group(32 patients)and a placebo group(32 patients)in a 1∶1 ratio in a randomized,double-blind,placebo-controlled trial.After sublingual administration of four capsules of Shexiang Tongxin Dripping Pill or the placebo,coronary angiography was repeated,and the corrected TIMI frame count(CTFC)and microcirculatory resistance index(caIMR)were measured to evaluate immediate blood flow velocity.After taking Shexiang Tongxin Dripping Pill or the placebo for 12 weeks,the short-term efficacy was evaluated using traditional Chinese medicine(TCM)syndrome,blood stasis syndrome,and Seattle Angina Questionnaire(SAQ)scores.Results The CTFC and caIMR were lower after administration in the Shexiang Tongxin Dripping Pill group(P＜0.05)than in the placebo group,and the differences in pre-and post-administration values between the two groups were significant(P＜0.01).Intragroup comparisons showed that the CTFC and caIMR in the Shexiang Tongxin Dripping Pill group were lower after administration than before administration(P＜0.01).After 12 weeks of treatment,the blood stasis and TCM syndrome scores in the Shexiang Tongxin Dripping Pill group were lower than those in the placebo group,whereas the SAQ score was higher than that in the placebo group(P＜0.01).Intragroup comparisons indicated that the blood stasis syndrome score in the Shexiang Tongxin Dripping Pill group was lower after treatment than before treatment,whereas the TCM syndrome score in both groups was lower and the SAQ score was higher after treatment than before treatment(P＜0.01).Conclusion Shexiang Tongxin Dripping Pill improve the immediate blood flow velocity of CSF,enhance the quality of life of patients,reduce the TCM syndrome and blood stasis syndrome scores,and have good safety.关键词
麝香通心滴丸/冠状动脉慢血流/冠状动脉微循环/随机对照试验Key words
Shexiang Tongxin Dripping Pill/coronary slow flow/coronary microcirculation/randomized controlled trial分类
医药卫生引用本文复制引用
刘用,胡慧,王云翠,肖狄,康静璠,张立晶..麝香通心滴丸改善冠状动脉慢血流即刻及短期疗效的临床研究[J].北京中医药大学学报,2025,48(5):605-612,8.基金项目
国家重点研发计划项目(No.2022YFC3500101) （No.2022YFC3500101）
北京中医药大学重点攻关项目(No.2020-JYB-ZDGG-116) National Key R&D Program(No.2022YFC3500101) （No.2020-JYB-ZDGG-116）
