北京中医药大学学报2025，Vol.48Issue(5)：636-645,10.DOI:10.3969/j.issn.1006-2157.2025.05.006
基于横断面调查的子宫腺肌病患者共病模式和中医证候特征分析
Multimorbidity pattern and traditional Chinese medicine syndrome characteristics of patients with adenomyosis:A cross-sectional study
摘要
Abstract
Objective To explore the multimorbidity pattern and traditional Chinese medicine(TCM)syndrome characteristics of patients with adenomyosis(AM)and to provide insights and data support for medical treatment and comprehensive AM management.Methods By retrospectively analyzing multi-center,large-sample,nationwide cross-sectional survey data,patients were divided into a single AM group or a multimorbidity group based on whether they had other diseases.The prevalence rates of specific multimorbidity or a combination of multimorbidities were calculated respectively.Single-factor analysis was used to explore the influence of age,course of disease,education level,labor nature,monthly income,production history,abortion history,operation history,region,and TCM syndromes on multimorbidity in patients with AM.The multimorbidity patterns of patients with AM were explored using Apriori association rules,and the distribution characteristics of TCM syndromes in different multimorbidity patterns were explored.Results Among 1,814 patients with AM,1,429 were in the multimorbidity group(prevalence of 78.78％).Compared with the single AM group,the patients in the multimorbidity group had a long disease course,high academic qualifications,jobs that mostly involved sitting,a history of surgery,and were primarily concentrated in the north(P＜0.05).The proportion of patients with qi stagnation and blood stasis syndrome decreased,whereas the proportion of patients with kidney deficiency and blood stasis syndrome increased.Ten multimorbidity association rules were sorted according to the confidence level,and the first place of binary association rules was breast nodule to breast hyperplasia,and the first place of ternary association rules was hysteromyoma,breast nodule to breast hyperplasia.Comprehensive support and confidence level,in the binary association rules,the strong association rule was breast nodule to thyroid nodule,and sub-strong association rule was thyroid nodule to breast hyperplasia;In the ternary association rules,the strong association rule was hysteromyoma,breast nodules to breast hyperplasia,and sub-strong association rule was endometriosis,thyroid nodules to breast hyperplasia.There was no significant difference in the distribution of TCM syndromes in AM patients with different binary and ternary multimorbidity patterns.Conclusion Patients with AM have different multimorbidity patterns,and the TCM syndromes of patients with AM under different multimorbidity patterns have different characteristics.The management system of AM multimorbidity should be further developed to ensure more comprehensive and standardized health management for patients with AM.关键词
子宫腺肌病/共病/关联规则/中医证候Key words
adenomyosis/multimorbidity/association rule/traditional Chinese medicine syndrome分类
医药卫生引用本文复制引用
王新,杨新春,赵瑞华..基于横断面调查的子宫腺肌病患者共病模式和中医证候特征分析[J].北京中医药大学学报,2025,48(5):636-645,10.基金项目
首都卫生发展科研专项(No.2022-1-4152) （No.2022-1-4152）
中华中医药学会妇科分会"子宫腺肌病流行病学调查"项目(No.[2020]045) （No.[2020]045）
中国中医科学院科技创新工程项目(No.CI2022C003) Capital's Funds for Health Improvement and Research(No.2022-1-4152) （No.CI2022C003）
