北京中医药大学学报2025，Vol.48Issue(5)：646-651,6.DOI:10.3969/j.issn.1006-2157.2025.05.007
基于三焦膜性管道论探讨系统性硬化病继发肺间质纤维化的病机及治疗
Exploration of the pathogenesis and treatment of pulmonary interstitial fibrosis secondary to systemic sclerosis based on the theory of sanjiao membranous channels
摘要
Abstract
Systemic sclerosis is an autoimmune rheumatic disease that often leads to multisystem diseases,frequently resulting in pulmonary interstitial fibrosis.According to the theory of sanjiao(triple energizers)membranous channels,sanjiao connects the five zang-organs and six fu-viscera internally and the skin,muscles,and bones externally.It serves as a four-way membranous channel that connects internal organs and external structures,linking with the micromembranes of organs and blood vessels.The pathogenesis of pulmonary interstitial fibrosis secondary to systemic sclerosis involves external cold obstructing the skin and interstitial layers,impairing the defense qi and defense yang,which originate in the essence of the kidney.This leads to weak defensive qi and kidney deficiency,causing stagnation in sanjiao's energy flow and disruption of water and gasification and loss of fluid,resulting in accumulation of dampness,phlegm,and blood stasis.These obstructive factors spread along sanjiao's membranous channels,leading to multiorgan micromembrane involvement and systemic damage.The lungs,which are in direct contact with the external environment,are particularly susceptible to invasion by external pathogens.When combined with stagnation of dampness,phlegm,and blood in the lungs,this leads to secondary pulmonary fibrosis,resulting in lung dysfunction.Continuous stagnation of sanjiao exacerbates the overall condition of the patient,leading to a mixed cold-heat imbalance.Treatment focuses on"unblocking,transforming,and regulating"to restore sanjiao function,promote qi and fluid circulation,invigorate blood,and adjust the cold-heat imbalance,ultimately restoring the overall condition of the patient.关键词
系统性硬化病/肺间质纤维化/三焦膜性管道论/脏腑微膜/疏利三焦Key words
systemic sclerosis/pulmonary interstitial fibrosis/theory of sanjiao(triple energizers)membranous channels/viscera and bowels micro-membrane/dredging and regulating triple energizers分类
中医学引用本文复制引用
孙云龙,张晓梅,杨天舒,李燕妮,李梦乾,赖宇鑫,谭新蕾,姜良铎..基于三焦膜性管道论探讨系统性硬化病继发肺间质纤维化的病机及治疗[J].北京中医药大学学报,2025,48(5):646-651,6.基金项目
首都卫生发展科研专项(No.2020-2-4202) （No.2020-2-4202）
北京中医药大学2024年基本科研业务费"揭榜挂帅"项目(No.2024-JYB-JBZD-009) Capital Health Development Research Special Project(No.2020-2-4202) （No.2024-JYB-JBZD-009）
