北京中医药大学学报2025，Vol.48Issue(5)：684-689,6.DOI:10.3969/j.issn.1006-2157.2025.05.013
从肠促胰岛素诠释"小肠泌别清浊"的学术内涵及其在痰湿体质调体中的临床应用
Academic interpretation of"small intestine separating purity from tur-bidity"theory and its clinical application in regulating phlegm-dampness constitution from incretin
摘要
Abstract
The phlegm-dampness constitution is a physical state characterized by the accumulation of stagnant water and fluid in the body,leading to the formation of phlegm-dampness,a common underlying factor in various metabolic diseases.The occurrence of this metabolic disorder is closely related to the small intestine.The concept of small intestine separating purity from turbidity describes the essential functions of the small intestine in digestion,absorption,and excretion.Dysfunction of the small intestine leads to metabolic disorders of phlegm-dampness constitution through three aspects of the action of phlegm-dampness obstructing qi movement,internal accumulation of phlegm-dampness leading to damage to yang qi,and phlegm and turbidity stagnating in the small intestine without clearance.However,the microscopic mechanisms remain unclear.One key factor in metabolic regulation is incretin,an intestinal hormone secreted by endocrine cells in the small intestine,which plays an essential role in maintaining metabolic balance.Inspired by the prescription thought of national medical master WANG Qi,the Yiqi Jianyun Decoction was developed to regulate the phlegm-dampness constitution.This prescription integrates key therapeutic principles such as Banxia Xiexin Decoction,benefiting qi and warming yang,as Sijunzi Decoction with modification,which supports qi nourishment and yang warming,and rhubarb root and rhizome,which facilitates small intestine clearance.These components effectively regulate incretin levels and improve overall metabolism.This article aims to provide a new scientific interpretation of the small intestine separating purity from turbidity theory from the perspective of incretins,enriching the modern scientific connotation of the pharmacological mechanism of Yiqi Jianyun Decoction,and providing a novel theoretical basis and prescription thought for the clinical intervention of the phlegm-dampness constitution,diagnosis and treatment of metabolic diseases.关键词
小肠泌别清浊/肠促胰岛素/代谢紊乱/痰湿体质Key words
small intestine separating purity from turbidity/incretin/metabolic disorder/phlegm-dampness constitution分类
医药卫生引用本文复制引用
孙浩文,万瑾毅,姚海强..从肠促胰岛素诠释"小肠泌别清浊"的学术内涵及其在痰湿体质调体中的临床应用[J].北京中医药大学学报,2025,48(5):684-689,6.基金项目
国家自然科学基金项目(No.82274379,No.82474371) （No.82274379,No.82474371）
北京中医药大学-优莎纳联合研究中心基金项目(No.K23-900201-028) （No.K23-900201-028）
北京中医药大学高层次人才项目(No.2021-XJ-KYOD-004) National Natural Science Foundation of China(Nos.82274379 and 82474371) （No.2021-XJ-KYOD-004）
