包装学报2025，Vol.17Issue(3)：69-78,10.DOI:10.20269/j.cnki.1674-7100.2025.3009
pH/葡萄糖双响应型抗菌水凝胶的制备及性能研究
Preparation and Performance of pH/Glucose Double-Responsive Antibacterial Hydrogel
摘要
Abstract
To address the limited environmental responsiveness of traditional medical dressings in controlled drug release,a pH/glucose dual-responsive drug-loaded hydrogel was developed through molecular design.Chitosan was functionalized via conjugation with 4-carboxyphenylboronic acid to synthesize boronic acid-modified chitosan(CSPBA),which was subsequently chemically crosslinked with polyvinyl alcohol(PVA)to form a hydrogel(CPP).The antibacterial agent polyhexamethylene biguanide hydrochloride(PHMB)was in situ encapsulated during the crosslinking process,enabling precise drug loading.The effects of CSPBA,PVA concentration and the CSPBA/PVA mass ratio on the hydrogel's microstructure,mechanical/rheological properties,drug release behavior,and antibacterial efficacy were systematically investigated.Results demonstrated that CPP exhibited robust mechanical strength and sustained drug release capability,achieving a cumulative release rate of 75.04％after 48 h under physiological conditions(37 ℃,pH 6.5,glucose-containing medium).In vitro antibacterial assays revealed remarkable inhibition rates of 99.45％and 99.07％against Escherichia coli and Staphylococcus aureus,respectively.The synergistic combination of controlled drug release and potent antimicrobial activity highlights CPP's promising potential in advanced wound management and functional biomedical applications.关键词
水凝胶/改性壳聚糖/聚乙烯醇/药物负载/抗菌Key words
hydrogel/modified chitosan/polyvinyl alcohol/drug load/antibacterial分类
化学化工引用本文复制引用
李佳新,卢嘉威,廖希智,李建平,陈一..pH/葡萄糖双响应型抗菌水凝胶的制备及性能研究[J].包装学报,2025,17(3):69-78,10.基金项目
国家自然科学基金资助项目(52073086) （52073086）
湖南省自然科学基金资助项目(2023JJ60447,2022JJ50058) （2023JJ60447,2022JJ50058）
