中国耳鼻咽喉头颈外科2025，Vol.32Issue(4)：205-209,5.DOI:10.16066/j.1672-7002.2025.04.001
喉软骨肉瘤预后相关因素分析
Analysis of prognostic factors for chondrosarcoma of the larynx
丁硕 1黄志刚 1房居高 1钟琦 1张洋 1侯丽珍 1郭伟1
作者信息
- 1. 首都医科大学附属北京同仁医院耳鼻咽喉头颈外科,耳鼻咽喉头颈科学教育部重点实验室(首都医科大学),北京 100730
- 折叠
摘要
Abstract
OBJECTIVE To investigate the prognostic factors of chondrosarcoma of the larynx,deeply analyze its clinical data,and provide a theoretical basis for better treatment of chondrosarcoma of the larynx.METHODS A retrospective analysis was conducted on the complete clinical data of patients with primary chondrosarcoma of the larynx admitted to the Department of Otolaryngology Head and Neck Surgery,Beijing Tongren Hospital,Capital Medical University from January 2010 to December 2024.RESULTS A total of 15 patients were included,including 11 males and 4 females,with a gender ratio of 11∶4.The average age of onset was 57.3 years,and the average clinical symptom duration was 12.2 months.The tumors were mainly located in the cricoid cartilage in 11 patients,in the arytenoid cartilage in 2 patients,and in the thyroid cartilage in 2 patients.Tumor grading showed that 7 patients were grade I and 8 were grade II.Four patients underwent transoral laser minimally invasive surgery,2 patients underwent partial laryngectomy+tracheotomy,and 9 patients underwent total laryngectomy/cervical lymph node dissection+tracheostomy.The 5-year overall survival rate was 85.7%,the 5-year disease-specific survival rate was 100%,and the 5-year local-regional control rate was 90.9%.Gender,tumor location,tumor grade,Ki-67,tumor size,and whether larynx preservation surgery was performed did not affect the local-regional control rate or disease-specific survival rate.CONCLUSION Laryngeal chondrosarcoma generally has a longer disease history and is difficult to detect.The pathological type is mostly well-differentiated.Regional or distant metastasis is rare,and the long-term survival rate is good.Surgical resection is the preferred treatment option.On the basis of not reducing the tumor control rate,surgery that prioritizes preserving laryngeal function should be given priority,while comprehensive treatment is generally not recommended.关键词
喉/软骨肉瘤/预后/外科手术Key words
Larynx/Chondrosarcoma/Prognosis/Surgical Procedures,Operative引用本文复制引用
丁硕,黄志刚,房居高,钟琦,张洋,侯丽珍,郭伟..喉软骨肉瘤预后相关因素分析[J].中国耳鼻咽喉头颈外科,2025,32(4):205-209,5.
