摘要
Abstract
OBJECTIVE The regression equation of cognitive impairment in patients with obstructive sleep apnea hypopnea syndrome(OSAHS)was constructed based on Logistic regression analysis,to lay a foundation for the prevention of cognitive impairment in OSAHS patients.METHODS A total of 302 OSAHS patients admitted to Huai'an First People's Hospital from October 2022 to October 2024 were selected for the study,and the cognitive impairment group(n=83)and the non-cognitive impairment group(n=219)were included according to the occurrence of cognitive impairment.The status quo of OSAHS patients complicated with cognitive impairment was analyzed,univariate and multivariate Logistic regression was used to analyze the early warning factors of OSAHS combined with cognitive impairment,regression equation was established,and receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of regression equation on OSAHS combined with cognitive impairment.RESULTS Among 302 OSAHS patients,83 cases were complicated with cognitive impairment(27.48%).Multivariate Logistic analysis showed that age increase,physical exercise<3 times/week,apnea hypopnea index increase,longest apnea duration prolongation,serum levels of neuropeptide Y(NPY)increase were early warning factors of OSAHS combined with cognitive impairment.The increase of minimum blood oxygen saturation and serum gamma-aminobutyric acid(GABA)were protective factors of OSAHS combined with cognitive impairment(P<0.05).The above factors were included in the regression equation:logit(P)=-1.875+age×0.059+physical exercise<3 times/week×0.041+apnea hypopnea index×0.031+longest apnea duration×0.073-minimum blood oxygen saturation×0.081+NPY×0.043-GABA×0.049.The regression equation was evaluated,and the likelihood ratio of Chi-square=7.632,DF=7,P<0.001,the regression equation was statistically significant.Patients with OSAHS combined with cognitive impairment were included as positive,while those OSAHS without cognitive impairment were included as negative.The ROC curve for predicting OSAHS combined with cognitive impairment was drawn according to the regression equation.The results showed that when logit(P)>2.02,the area under the curve(AUC)was 0.896.The diagnostic sensitivity and specificity were 85.54%and 83.56%respectively.CONCLUSION OSAHS patients with cognitive impairment were not optimistic,early warning factors included increasing age,less than 3 times/week of physical exercise,increased apnea hypopnea index,prolonged longest apnea time,elevated serum NPY,protective factors included elevated minimum blood oxygen saturation and elevated serum GABA,the regression equation constructed on this basis had good predictive value.关键词
认知障碍/阻塞性睡眠呼吸暂停低通气综合征/预警因素/回归方程/受试者工作特征曲线Key words
Cognition Disorders/obstructive sleep apnea hypopnea syndrome/early warning factors/regression equation/receiver operating characteristic curve
