发光学报2025，Vol.46Issue(5)：830-846,17.DOI:10.37188/CJL.20240284
基于二氧杂环丁烷中间体的余辉发光材料构建与生物成像研究进展
Research Progress in Development of Dioxetane Intermediates-based Afterglow Luminescent Materials and Their Applications in Bioimaging
摘要
Abstract
The afterglow imaging technology avoids the interference of biological tissue autofluorescence and has ul-tra-high imaging signal-to-noise ratio,showing great application prospects in the field of biomedical imaging.The generation and decomposition of high-energy dioxetane intermediates enable the storage and release of light energy.As a result,afterglow materials that can be oxidized by singlet oxygen to form dioxetane intermediates exhibit pro-longed luminescence.The dioxetane intermediates-based afterglow luminescent materials have good biocompatibility and structural diversity,and can extend the afterglow emission range and enhance afterglow intensity through struc-tural modification,achieving more accurate afterglow imaging.This review summarizes the luminescence mechanism and construction strategies of dioxetane-based afterglow materials,introduces the design strategies of multi-compo-nent and single-molecule afterglow materials,and discusses in detail the reported afterglow substrates and their lumi-nescence mechanisms.Moreover,the design strategies of afterglow nanoprobes and their latest developments in disease diagnosis,biosensing,and imaging were discussed and classified.Finally,the challenges and future devel-opment prospects of this type of material in clinical translation were analyzed.关键词
余辉发光/二氧杂环丁烷/余辉材料/疾病诊断/生物成像Key words
afterglow luminescence/dioxetane/afterglow material/disease diagnosis/biological imaging分类
物理学引用本文复制引用
王楠楠,姬盛路,丁丹..基于二氧杂环丁烷中间体的余辉发光材料构建与生物成像研究进展[J].发光学报,2025,46(5):830-846,17.基金项目
河南省科技攻关项目(242102230116) （242102230116）
河南省高等学校重点科研项目计划(25A430012) Supported by Scientific and Technological Research Project of Henan Province(242102230116) （25A430012）
Key Scientific Research Proj-ect of Colleges and Universities in Henan Province(25A430012) （25A430012）
