赣南医科大学学报2025，Vol.45Issue(4)：313-321,9.DOI:10.3969/j.issn.1001-5779.2025.04.001
核酸感应模式识别受体在机体抗白念珠菌感染中的作用研究进展
Research progress in the roles of nucleic acid-sensing pattern recognition receptors in the host defense against Candida albicans infection
摘要
Abstract
Many commensal organisms exist in the normal human body,and Candida albicans is one of the more common commensal fungi.Candida albicans transforms from a normal to a pathogenic fungus when there is a disturbance in the immune system.The host triggers an innate immune response to recognize pathogenic bacteria and fight against infection mainly through pattern recognition receptors(PRRs),including Toll-like receptors(TLRs),NOD-like receptors(NLRs),RIG-Ⅰ-like receptors(RLRs),AIM2-like receptors(ALRs)and C-type lectin-like receptors(CLRs).PRRs that recognise nucleic acids of foreign or self-pathogens are known as nucleic acid-sensing PRRs.On the one hand,some nucleic acid-sensing PRRs mediate the secretion of chemokines and cytokines to fight against Candida albicans infections via neutrophils or produce interferons to protect the host from invasion.On the other hand,these receptors can promote host infection by inhibiting AKT activation,enhancing macrophage apoptosis and impairing phagocytosis and bactericidal function of macrophages.This review will discuss the important roles of nucleic acid-sensing PRRs in the host defense against Candida albicans infection and its complex mechanism,which will bring new insights and directions for future clinical treatment of Candida albicans infection.关键词
受体,模式识别/核酸/白念珠菌/免疫系统/细胞因子Key words
Receptors,pattern recognition/Nucleic acid/Candida albicans/Immune system/Cytokine分类
基础医学引用本文复制引用
席毓灵,隋丽娜,郑思平,何良梅,江茜,刘志平..核酸感应模式识别受体在机体抗白念珠菌感染中的作用研究进展[J].赣南医科大学学报,2025,45(4):313-321,9.基金项目
国家自然科学基金项目(31960163,32260191) （31960163,32260191）
井冈学者科研启动基金项目(QD202205) （QD202205）
江西省自然科学基金青年项目(20224BAB216070) （20224BAB216070）
赣南医学院第一附属医院博士启动基金项目(QD202225) （QD202225）
赣南医学院第一附属医院院级科技计划项目基金项目(YJZD202007) （YJZD202007）
