赣南医科大学学报2025，Vol.45Issue(4)：329-333,5.DOI:10.3969/j.issn.1001-5779.2025.04.003
冷冻疗法联合当归四逆汤对白蛋白结合型紫杉醇化疗诱导的周围神经病变的疗效观察
Observation of therapeutic effect of cryotherapy combined with Danggui Sini decoction on peripheral nerve toxicity induced by albumin-bound paclitaxel
摘要
Abstract
Objective:To observe the clinical effect and safety of cryotherapy combined with Danggui Sini decoction on the peripheral nerve toxicity caused by albumin-bound paclitaxel chemotherapy.Methods:Sixty patients with advanced non-small cell lung squamous cell carcinoma from September 2022 to December 2023 were randomly divided into control group and experimental group.The control group received albumin-bound paclitaxel combined chemotherapy,and the experimental group received cryotherapy plus Danggui Sini decoction on the basis of chemotherapy.The incidence and grading of peripheral nerve toxicity,European organization of research and treatment of cancer QLQ-CIPN20(EORTC QLQ-CIPN20),Clinical assessment scale for chemotherapy-induced peripheral neuropathy(CAS-CIPN),Karnofsky performance status(KPS),myelosuppression,liver and kidney function were observed and analyzed between the two groups during chemotherapy.Results:The incidence and grade of peripheral nerve toxicity in the experimental group after 2,4 and 6 cycles of chemotherapy were significantly lower than those in the control group(P＜0.05).The EORTC QLQ-CIPN20 scores in the experimental group after 2,4 and 6 cycles of chemotherapy were significantly lower than those in the control group(P＜0.05).The CAS-CIPN scores of the experimental group were significantly lower than those of the control group after 2,4 and 6 cycles of chemotherapy(P＜0.05).The KPS scores of the experimental group aafter 2,4 and 6 cycles of chemotherapy were higher than those of the control group(P＜0.05).The incidence of myelosuppression was similar between the two groups,with no statistical significance(P＞0.05).Both groups of patients had no significant abnormalities in liver and kidney function.Conclusion:Cryotherapy combined with Danggui Sini decoction can effectively reduce the incidence and severity of peripheral nerve toxicity after albumin-bound paclitaxel chemotherapy,improve patients'quality of life,improve treatment compliance,and is safe and reliable.关键词
冷冻疗法/当归四逆汤/白蛋白结合型紫杉醇/周围神经Key words
Cryotherapy/Danggui Sini decoction/Albumin-bound paclitaxel/Peripheral nerves分类
临床医学引用本文复制引用
钟文娟,何苗,曾小莉,施华球,汪胜军,吴书贵..冷冻疗法联合当归四逆汤对白蛋白结合型紫杉醇化疗诱导的周围神经病变的疗效观察[J].赣南医科大学学报,2025,45(4):329-333,5.基金项目
江西省中医药管理局科技计划项目(2022B009) （2022B009）
