摘要
Abstract
Objective:To analyze the preoperative predictive value of conventional clinical indicators for the staging and classification of gastric cancer.Methods:The preoperative clinical data of gastric cancer patients who were hospitalized and pathologically diagnosed in Ganzhou Municipal Hospital from January 2015 to December 2020 was collected,including gastroscopy,biopsy pathology,CT examination,routine blood tests,and postoperative pathology.Multivariate and multicategorical logistic regression analysis was performed to evaluate the preoperative predictive value of the combination of clinical and pathological indicators for pathological TNM(pTNM)stage,depth of invasion,and subgroup based on treatment method.Results:A total of 440 gastric cancer patients were included in the analysis,292 males and 148 females,with an average age of(60.9±10.7)years,of whom 95 were in stage Ⅰ,54 in stage Ⅱ,263 in stage Ⅲ,and 28 in stage Ⅳ.A total of 28 indicators from gastroscopy,biopsy pathology,CT and routine blood laboratory tests were statistically significant among different pTNM stages of gastric cancer(P＜0.05),of which 6 indicators(tumor size on gastroscopy,gastric cancer stage on gastroscopy,lymph node enlargement on CT,distant metastasis on CT,serum total bile acids and CA125)had independent predictive value for preoperative pTNM stage,and the model developed using them had the overall accuracy of 75.0%(330/440)in predicting pTNM stage,88.9%(391/440)in predicting tumor inva-sion of mucosa,muscle or serous layer,and 91.6%(403/440)in predicting three types of gastric cancer suitable for endo-scopic treatment,radical surgical resection or comprehensive treatment.Conclusion:The combination of conventional clinical indicators has a good preoperative predictive value for pTNM stage,depth of invasion and appropriate therapy mo-dality of gastric cancer.关键词
胃肿瘤/临床分期/浸润深度/临床分类/临床指标/术前预测Key words
Gastric tumor/Pathological TNM staging/Invasion depth/Clinical classification/Clinical indicators/Preoperative prediction分类
临床医学
