医学分子生物学杂志2025，Vol.22Issue(3)：266-270,5.DOI:10.3870/j.issn.1672-8009.2025.03.009
MCUR1在三阴性乳腺癌中的表达及其临床预后价值
Expression and Clinical Prognostic Value of MCUR1 in Triple-nega-tive Breast Cancer
摘要
Abstract
Objective To analyze the expression of mitochondrial calcium uniporter regulator 1(MCUR1)in triple-negative breast cancer(TNBC)and its clinical significance.Methods Immu-nohistochemistry was used to detect the expression of MCUR1 protein in TNBC tissues and corre-sponding adjacent tissues of 98 patients.The relationship between MCUR1 expression in tumor tissues and patients'clinicopathological features and overall survival was further analyzed.Results MCUR1 was overexpressed in TNBC,and its expression level was significantly higher than that in the adja-cent tissues(t=34.58,P＜0.01).Clinicopathological analysis showed that high MCUR1 expres-sion in TNBC was significantly correlated with tumor grade,T stage,and TNM stage(P＜0.05,respectively).Further survival analysis showed that patients with high expression level of MCUR1 had a lower overall survival rate than those with low expression level(x2=4.591,P=0.032),which was an independent risk factor for poor prognosis of TNBC(HR=2.106,95％CI:1.013-5.628,P=0.035).Conclusion The expression of MCUR1 in TNBC tissues is up-regulated,and its high expression is associated with tumor progression and poor prognosis,which is a potential bio-marker to evaluate the prognosis of TNBC patients.关键词
三阴性乳腺癌/线粒体钙单向转运体调节分子1/免疫组织化学/临床病理特征/预后Key words
triple-negative breast cancer/mitochondrial calcium uniporter regulator 1/immu-nohistochemistry/clinicopathological features/prognosis分类
临床医学引用本文复制引用
付雨星,彭茜,杨朝纲..MCUR1在三阴性乳腺癌中的表达及其临床预后价值[J].医学分子生物学杂志,2025,22(3):266-270,5.基金项目
湖北省自然科学基金(No.2021CFB100) This work was supported by a grant from the Natural Science Foundation of Hubei Province(No.2021CFB100) （No.2021CFB100）
