河北医学2025，Vol.31Issue(5)：756-760,5.DOI:10.3969/j.issn.1006-6233.2025.05.09
晚期肺癌化疗肺部感染患者的病原学特点及HMGB1 MMP-9联合预测价值分析
Etiological Characteristics of Pulmonary Infection in Patients Undergoing Chemotherapy for Advanced Lung Cancer and the Predictive Value of HMGB1 Combined with MMP-9
摘要
Abstract
Objective:To investigate the etiological characteristics of pulmonary infection in patients un-dergoing chemotherapy for advanced lung cancer and the predictive value of high mobility group box 1(HMGB1)combined with matrix metalloproteinase-9(MMP-9).Methods:A total of 118 patients who un-derwent chemotherapy for advanced lung cancer in the Second Affiliated Hospital of Air Force Medical Univer-sity from June 2023 to June 2024 were selected,and divided into the infected group(n=51)and the unin-fected group(n=67)based on whether they developed pulmonary infection after chemotherapy.Sputum sam-ples were collected from the infected group for etiological examination.The levels of HMGB1 and MMP-9 in the two groups were compared.Logistic regression analysis was performed to identify factors influencing pulmo-nary infection in patients undergoing chemotherapy for advanced lung cancer.The receiver operating character-istic(ROC)curve was used to evaluate the predictive efficacy of HMGB1 combined with MMP-9 levels for pulmonary infection.Results:In this study,51 patients developed pulmonary infection.A total of 64 strains of pathogenic bacteria were isolated,including 39 strains(60.94%)of Gram-negative bacteria,20 strains(31.25%)of Gram-positive bacteria,and 5 strains(7.81%)of fungi.The levels of HMGB1 and MMP-9 in the infected group were higher than those in the uninfected group(P<0.05).Logistic regression analysis showed that HMGB1 and MMP-9 levels were risk factors for pulmonary infection(P<0.05).The area under the curve(AUC),sensitivity and specificity of HMGB1 were 0.806,56.86%and 94.03%(P<0.05).The AUC,sensitivity and specificity of MMP-9 were 0.838,62.75%and 92.54%(P<0.05).The AUC,sensi-tivity and specificity of HMGB1 combined with MMP-9 were 0.905,72.55%and 92.54%(P<0.05).Con-clusion:Gram-negative bacteria are main pathogenic bacteria of pulmonary infection in patients undergoing chemotherapy for advanced lung cancer.The levels of HMGB1 and MMP-9 are significantly elevated in pa-tients with pulmonary infection.Combination of HMGB1 and MMP-9 can improve clinical diagnostic efficacy for pulmonary infection in patients undergoing chemotherapy for advanced lung cancer.关键词
晚期肺癌化疗/肺部感染/病原学特点/高迁移率族蛋白B1/基质金属蛋白酶-9/预测价值Key words
Chemotherapy for advanced lung cancer/Pulmonary infection/Etiological character-istic/High mobility group box 1/Matrix metalloproteinase-9/Predictive value引用本文复制引用
张红佩,金发光,任腾..晚期肺癌化疗肺部感染患者的病原学特点及HMGB1 MMP-9联合预测价值分析[J].河北医学,2025,31(5):756-760,5.基金项目
陕西省重点研发计划项目,(编号:20222DLSP01-10) （编号:20222DLSP01-10）
