河北医学2025，Vol.31Issue(5)：761-765,5.DOI:10.3969/j.issn.1006-6233.2025.05.010
高血压肾病患者凝血指标与同型半胱氨酸β2微球蛋白水平及终末期肾病发生的关系研究
Study on Correlation between Coagulation Indexes and Homocysteine β2 Microglobulin and Occurrence of End-Stage Renal Disease in Patients with Hypertensive Nephropathy
摘要
Abstract
Objective:To analyze the correlation between coagulation indexes and homocysteine(Hcy),β2-microglobulin(β2-MG)and occurrence of end-stage renal disease(ESRD)in patients with hypertensive nephropathy(HN).Methods:A total of 138 patients with HN in the hospital from August 2019 to August 2021 were selected as the study group.According to the occurrence of ESRD after 3 years of follow-up,the a-bove patients were divided into ESRD group(n=26)and non-ESRD group(n=112).In addition,102 hy-pertensive patients without nephropathy who received examination in the hospital during the same period were included in the control group.The levels of coagulation indexes[D-dimer(D-D),fibrinogen(Fib),fibrin-ogen degradation product(FDP)],Hcy and β2-MG were measured among all study subjects.The correlation between D-D,Fib and FDP levels and Hcy and β2-MG levels in hypertensive nephropathy patients was ana-lyzed by Pearson correlation,and the correlation between D-D,Fib and FDP levels and the occurrence of end-stage nephropathy in hypertensive nephropathy patients was analyzed by Logistic regression.Results:The levels of serum D-D,Fib,FDP,Hcy and β2-MG in the study group were higher than those in the control group(P<0.05).Serum D-D,Fib,FDP,Hcy and β2-MG levels were higher in the ESRD group than those in the non-ESRD group(P<0.05).Correlation analysis indicated that serum D-D,Fib and FDP levels were positively correlated with Hcy and β2-MG levels in patients with HN(r=0.771,0.795;0.568,0.619;0.545,0.591,P<0.05).The levels of D-D,Fib and FDP in hypertensive nephropathy patients were independ-ent risk factors for end-stage nephropathy(P<0.05).Conclusion:The levels of D-D,Fib and FDP in hy-pertensive nephropathy patients were positively correlated with the levels of Hcy,β2-MG and end-stage ne-phropathy.关键词
高血压肾病/终末期肾病/凝血指标/同型半胱氨酸/β2微球蛋白/相关性Key words
Hypertensive nephropathy/End-stage renal disease/Coagulation indexes/Homo-cysteine/β2-microglobulin/Correlation引用本文复制引用
白若玥,李琴..高血压肾病患者凝血指标与同型半胱氨酸β2微球蛋白水平及终末期肾病发生的关系研究[J].河北医学,2025,31(5):761-765,5.基金项目
陕西省自然科学基础研究计划项目,(编号:2024JC-YBQN-0819) （编号:2024JC-YBQN-0819）
