河北医学2025，Vol.31Issue(5)：770-777,8.DOI:10.3969/j.issn.1006-6233.2025.05.012
血清CCL19 HMGB1 IFN-γ对妊娠期系统性红斑狼疮患者围产结局预测价值
The Predictive Value of Serum CCL19 HMGB1 IFN-γ for Perinatal Outcomes in Patients with Systemic Lupus Erythematosus during Pregnancy
摘要
Abstract
Objective:To analyze the predictive value of serum chemokine ligand 19(CCL19),high mobility protein-1(HMGB1),and interferon-γ(IFN-γ)for perinatal outcomes in patients with systemic lupus erythematosus(SLE)during pregnancy.Methods:A total of 180 pregnant SLE patients treated in our hospital from January 2022 to January 2024 were selected and divided into an adverse group(n=41)and a good group(n=139)according to perinatal outcomes.Another 41 non-pregnant SLE patients treated in our hospital during the same period were selected as the control group.Serum levels of CCL19,HMGB1 and IFN-γ were compared between the three groups.logistic regression analysis was conducted to analyze the influen-cing factors of adverse perinatal outcomes in SLE patients during pregnancy,and the predictive efficacy of ser-um CCL19,HMGB1,and IFN-γ in SLE patients during pregnancy was analyzed by receiver operating curve(ROC).Results:Serum levels of CCL19,HMGB1 and IFN-γ in adverse group were higher than those in good group and control group(F=1184.610,180.557,487.362,P<0.05).Serum levels of CCL19,HMGB1 and IFN-γ in the good group were higher than those in the control group(P<0.05).Logistic regres-sion analysis showed that,CCL19[OR(95%CI):2.036(1.037～4.317)],HMGB1[OR(95%CI):1.982(1.130～3.592)],IFN-γ[OR(95%CI):3.936(1.392～5.284)],Raynaud's phenomenon[OR(95%CI):1.818(1.057～3.269)],SLE disease activity score(SLEDAI)[OR(95%CI):2.387(1.047～4.082)]are risk factors for adverse perinatal outcomes in pregnant SLE patients(P<0.05).ROC curve a-nalysis showed that the area under the curve(AUC)of the combined detection of serum CCL19,HMGB1,and IFN-γ for predicting adverse perinatal outcomes in pregnant SLE patients was 0.873,with a 95%confi-dence interval of 0.816～0.931.The AUC of the combined detection of serum CCL19,HMGB1,and IFN-γ was higher than that of single detection(Z/P=2.402/0.013,2.598/0.009,2.710/0.006).Conclusion:Overexpression of serum CCL19,HMGB1,and IFN-γ in pregnant SLE patients is closely associated with adverse perinatal outcomes.Combined detection of serum CCL19,HMGB1,and IFN-γ can improve the predictive power of adverse perinatal outcomes in pregnant SLE patients.关键词
系统性红斑狼疮/趋化因子配体19/高迁移率蛋白-1/干扰素-γ/妊娠/围产结局Key words
Systemic lupus erythematosus/Chemokine ligand 19/High mobility protein-1/In-terferon gamma/Pregnancy/Perinatal outcome引用本文复制引用
符艳艳,徐豫湘,刘文娥..血清CCL19 HMGB1 IFN-γ对妊娠期系统性红斑狼疮患者围产结局预测价值[J].河北医学,2025,31(5):770-777,8.基金项目
湖南省重点研发计划,(编号:2023SK2050) （编号:2023SK2050）
