河北医学2025，Vol.31Issue(5)：783-788,6.DOI:10.3969/j.issn.1006-6233.2025.05.014
中性粒细胞凝血参数与全膝关节置换术后深静脉血栓发生的关系研究
Study on Correlation between Neutrophil Coagulation Parameters and Deep Venous Thrombosis Occurrence after Total Knee Arthroplasty
摘要
Abstract
Objective:To analyze the correlation between neutrophil count(NC),coagulation parame-ters and deep venous thrombosis(DVT)after total knee arthroplasty(TKA).Methods:Totally 364 patients who received TKA in the hospital from September 2022 to September 2023 were divided into thrombosis group(n=42)and non-thrombosis group(n=322)according to whether DVT occurred after surgery.Peripheral blood NC,D-D,Fib,APTT,PT and TT of all study subjects were measured at 3 days after surgery.Logistic regression analysis was adopted to explore the relationship between NC and coagulation parameters with the oc-currence of DVT after TKA.The predictive value of NC and coagulation parameters on the occurrence of post-operative DVT was investigated by receiver operating characteristic curve(ROC).Results:At 3 days after surgery,the levels of NC,D-D,and Fib in the thrombosis group were higher than those in the non-thrombo-sis group(P<0.05),but there were no obvious differences in APTT,PT and TT between groups(P>0.05).Logistic regression analysis suggested that the levels of NC,D-D,and Fib were independent risk factors of DVT occurrence after TKA(P<0.05).ROC curve showed that 3 days after surgery,the area under the curve(AUC)of NC,D-D,and Fib independently predicted the occurrence of deep vein thrombosis after total knee replacement was 0.636,0.724 and 0.664,respectively,and the sensitivity was 45.24%,47.62%and 66.67%,respectively.The specificity was 81.68%,88.82%,64.60%,respectively.The AUC of the combined prediction was 0.905,the sensitivity was 85.71%,and the specificity was 80.43%.The combined prediction efficiency was better than that of each index alone(P<0.05).Conclusion:The occurrence of DVT after TKA is closely related to the postoperative NC and coagulation parameters.The determination of NC and coagulation parameters after surgery can be used to understand the risk of lower extremity DVT,to guide clinical early pre-vention and treatment measures.关键词
全膝关节置换术/下肢深静脉血栓/中性粒细胞/凝血参数/相关性/预测价Key words
Total knee arthroplasty/Lower extremity deep venous thrombosis/Neutrophil/Co-agulation parameters/Correlation/Predictive value引用本文复制引用
地里阿热·尔肯,吾湖孜·吾拉木,徐艺,刘静雅,李真真..中性粒细胞凝血参数与全膝关节置换术后深静脉血栓发生的关系研究[J].河北医学,2025,31(5):783-788,6.基金项目
国家自然科学基金资助项目,(编号:82002276) （编号:82002276）
2023年度"青年科研启航"专项基金项目,(编号:2023YFY-QKMS-05) （编号:2023YFY-QKMS-05）
第二批"天山英才"-青年托举人才项目,(编号:2023TSYCQNTJ0018) （编号:2023TSYCQNTJ0018）
