河北医学2025，Vol.31Issue(5)：788-794,7.DOI:10.3969/j.issn.1006-6233.2025.05.015
血清IGF-1 VEGF TSH指数表达水平与脑小血管病认知障碍进展至痴呆的相关性分析
Correlation Analysis of Serum IGF-1 VEGF and TSH Index Expression Levels with the Progression of Cognitive Impairment to Dementia in Patients with Cerebral Small Vessel Disease
摘要
Abstract
Objective:To explore the correlation between the expression levels of serum insulin-like growth factor-1(IGF-1),vascular endothelial growth factor(VEGF),and thyroid-stimulating hormone(TSH)index,and the progression of cognitive impairment to dementia in cerebral small vessel disease(CS-VD),to provide a reference for clinical prevention and treatment.Methods:A total of 210 CSVD patients with cognitive impairment admitted to the hospital from May 2020 to May 2023 were selected and treated with symptomatic treatment.They were followed up for 1 year and assigned to a dementia group and a non-demen-tia group based on whether their cognitive impairment progressed to dementia.Clinical data were collected from all patients,and 5 mL of fasting venous blood was collected early in the morning of the day following the admission of all patients to detect the levels of serum IGF-1,VEGF,and TSH indices.The clinical data,ser-um levels of IGF-1,VEGF,and TSH indices were compared between the two groups,the correlation between serum levels of IGF-1,VEGF,and TSH indices and the severity of cognitive impairment and dementia was analyzed,the predictive value of each serum marker for the progression of CSVD cognitive impairment to de-mentia was evaluated.Results:Compared with the non-dementia group,the dementia group had higher pro-portions of alcohol consumption,family history of dementia,and total CSVD imaging burden scores at base-line,as well as lower MoCA scores and proportions of regular anti-cognitive impairment treatment at baseline(all P<0.05).Compared with the non-dementia group(97.28±14.15)ng/mL,(248.77±40.61)ng/L,and(133.27±13.58)mIU/L,the dementia group had lower serum IGF-1 and VEGF levels[(83.65±10.40)ng/mL and(210.49±35.23)ng/L,respectively],and a higher TSH index level(151.45±18.72)mIU/L(t=5.471,5.762,6.791,all P<0.05);serum IGF-1 and VEGF were negatively correlated with the total burden score of CSVD imaging at baseline,and positively correlated with MoCA score;the TSH index was positively correlated with the total burden score of CSVD imaging at baseline,and negatively correlated with MoCA score(P<0.05).Before and after correcting other factors,serum IGF-1,VEGF,and TSH indi-ces were still independently associated with the progression of CSVD cognitive impairment to dementia(P<0.05).The AUCs of serum IGF-1,VEGF,and TSH index for predicting the progression of CSVD cognitive im-pairment to dementia were 0.776(95%CI:0.713～0.831),0.812(95%CI:0.752～0.863),and 0.821(95%CI:0.762～0.871),respectively;the AUC of the three combined predictors for the progression of CS-VD cognitive impairment to dementia was 0.932(95%CI:0.888～0.962),with a sensitivity of 88.89%and a specificity of 84.71%;the predictive value was significantly higher than that of each predictor(P<0.05).Conclusion:The serum levels of IGF-1,VEGF,and TSH indices are significantly correlated with the condi-tion of patients with CSVD cognitive impairment,which are independent factors contributing to the progression to dementia,and their combined predictive value is reliable.关键词
脑小血管病/认知障碍/痴呆/胰岛素样生长因子-1/血管内皮生长因子/促甲状腺激素指数Key words
Cerebral small vessel disease/Cognitive impairment/Dementia/Insulin-like growth factor-1/Vascular endothelial growth factor/Thyroid stimulating hormone index引用本文复制引用
白彦昌,陈善鹏,孙倩玉,张亚杰..血清IGF-1 VEGF TSH指数表达水平与脑小血管病认知障碍进展至痴呆的相关性分析[J].河北医学,2025,31(5):788-794,7.基金项目
河北省重点研发计划项目,(编号:20019702813D) （编号:20019702813D）
