河北医学2025，Vol.31Issue(5)：794-800,7.DOI:10.3969/j.issn.1006-6233.2025.05.016
血清ANGPTL8 CXCL16水平与全膝关节置换术后下肢深静脉血栓的相关性
Correlation between Serum ANGPTL8 and CXCL16 Levels and Lower Limb Deep Vein Thrombosis after Total Knee Replacement
摘要
Abstract
Objective:To investigate the expression levels of angiopoietin like protein 8(ANGPTL8)and CXC chemokine ligand 16(CXCL16)in serum of patients undergoing total knee replacement,and their correlation with lower extremity deep vein thrombosis.Methods:A total of 110 patients who underwent total knee arthroplasty at our hospital between December 2016 and June 2022 were enrolled.Serum ANGPTL8 and CXCL16 levels were measured by enzyme-linked immunosorbent assay(ELISA)preoperatively and 7 days postoperatively for comparison.Patients were divided into non-deep vein thrombosis(non-DVT)group(n=76)and deep vein thrombosis(DVT)group(n=34)based on whether they developed lower extremity DVT.General characteristics were compared between the two groups.Pearson correlation analysis was performed to examine:1)the correlation between serum ANGPTL8 and CXCL16 levels,and 2)their association with DVT occurrence.Multivariate logistic regression analysis was conducted to identify risk factors for DVT in TKA pa-tients.Receiver operating characteristic(ROC)curve analysis was used to evaluate the predictive value of se-rum ANGPTL8 and CXCL16 levels for DVT development.Results:7 days after the surgery of total knee re-placement,Serum ANGPTL8 and CXCL16 were significantly lower than preoperative(t=9.189,5.773,P=0.000)and serum ANGPTL8 and CXCL167d in lower extremity deep veinthrornbosis group was higher than that in non lowere extremity deep vein thrombosis group(t=1.96 1,7.580,1.029,8.095,P=0.052,0.000,0.306,0.000);there were obvious differences in age,hypertension history,operation time,bed rest time and body mass index between lower extremity deep vein thrombosis group and non lower extremity deep vein throm-bosis group(P<0.05);the levels of serum ANGPTL8 and CXCL16 were obviously and positively correlated with the occurrence of lower extremity deep vein thrombosis(r=0.728,0.856,P=0.001,0.000);there was a obvious positive correlation between serum ANGPTL8 level and CXCL16 level in patients with total knee replacement(r=0.538,P=0.000);serum ANGPTL8,CXCL16,history of hypertension,operation time and bed rest time after operation were the influencing factors of lower extremity deep vein thrombosis in pa-tients undergoing total knee replacement(P<0.05);the AUC predicted by the combination of serum AN-GPTL8 and CXCL16 in patients undergoing total knee replacement was 0.986,with a sensitivity of 94.12%and a specificity of 95.37%,which was better than their separate prediction(Zcombination-ANGPTL8=2.193,Zcombination-CXCL16=2.343,P=0.028,0.019).Conclusion:The levels of serum ANGPTL8 and CXCL16 in patients with total knee replacement 7 days after operation are obviously lower than those before operation,in addition,patients with lower extremity deep vein thrombosis have higher levels of serum AN-GPTL8 and CXCL16,the combined detection of the two can better evaluate the occurrence of lower extremity deep vein thrombosis in patients undergoing total knee replacement.关键词
全膝关节置换术/血管生成素样蛋白8/CXC趋化因子配体16/下肢深静脉血栓Key words
Total knee replacement/Angiopoietin like protein 8/CXC chemokine ligand 16/Lower extremity deep vein thrombosis引用本文复制引用
田志明,段旭华,李永顺,童天夫..血清ANGPTL8 CXCL16水平与全膝关节置换术后下肢深静脉血栓的相关性[J].河北医学,2025,31(5):794-800,7.基金项目
江苏省卫生健康委员会科研项目,(编号:20203261) （编号:20203261）
