河北医学2025，Vol.31Issue(5)：800-806,7.DOI:10.3969/j.issn.1006-6233.2025.05.017
ABCD2评分联合外周血Hcy GSH-Px水平预测短暂性脑缺血发作患者预后的价值分析
Value of ABCD2 Score Combined with Peripheral Blood Hcy and GSH-Px Levels on Predicting the Prognosis of Patients with Transient Ischemic Attack
摘要
Abstract
Objective:To explore the value of ABCD2 score combined with peripheral blood homocys-teine(Hcy)and glutathione peroxidase(GSH-Px)levels on predicting the prognosis of patients with transi-ent ischemic attack(TIA).Methods:A total of 126 patients with TIA from December 2022 to August 2024 were retrospectively analyzed and included in TIA group.According to whether acute cerebral infarction oc-curred within 7 days,the patients in TIA group were divided into ACI group(n=29)and non-ACI group(n=97).The baseline data,ABCD2 score and peripheral blood indexes(Hcy,GSH-Px)were compared be-tween ACI group and non-ACI group.ABCD2 score and peripheral blood indexes(Hcy,GSH-Px)were compared between ACI group and non-ACI group.Pearson correlation analysis was used to explore the corre-lation between each index and clinical data.Binary logistic equation was adopted to analyze the related influ-encing factors of acute cerebral infarction in patients.ROC curve was drawn to analyze the diagnostic value of ABCD2 score combined with peripheral blood Hcy and GSH-Px levels on the prognosis in TIA group.Re-sults:Hypertension,diabetes,attack duration,attack frequency,TC and TG in ACI group were significantly higher than those in non ACI group(P<0.05).The ABCD2 scores and peripheral blood Hcy levels in the ACI group were significantly higher than those in the non ACI group(P<0.05),while GSH Px was signifi-cantly lower than those in the non ACI group(P<0.05).ABCD2 score and Hcy were significantly positively correlated with attack duration,attack frequency,TC and TG(P<0.05),and GSH-Px was significantly neg-atively correlated with each index(P<0.05).The ABCD2 score and peripheral blood Hcy level in ACI group were significantly higher(P<0.05)while the GSH-Px was significantly lower compared to non-ACI group(P<0.05).ABCD2 score and levels of Hcy and GSH-Px in peripheral blood were correlated with acute cerebral infarction(P<0.05).The AUCs of ABCD2 score,peripheral blood Hcy and GSH-Px in predicting the poor prognosis of patients were 0.638,0.677 and 0.701 respectively.The AUC of the combination of the three in-dexes for poor prognosis of patients was 0.770,and the combined diagnostic value was higher.Conclusion:ABCD2 score and levels of peripheral blood Hcy and GSH-Px are correlated with transient ischemic attack and poor prognosis,which are expected to be used as reference indexes.关键词
短暂性脑缺血/急性脑梗死/ABCD2评分/同型半胱氨酸/谷胱甘肽过氧化物酶Key words
Transient ischemic attack/Acute cerebral infarction/ABCD2 score/Homocys-teine/Glutathione peroxidase引用本文复制引用
王一旭,张静..ABCD2评分联合外周血Hcy GSH-Px水平预测短暂性脑缺血发作患者预后的价值分析[J].河北医学,2025,31(5):800-806,7.基金项目
陕西省自然科学基础研究计划项目,(编号:2022JQ-854) （编号:2022JQ-854）
