河北医学2025，Vol.31Issue(5)：824-827,4.DOI:10.3969/j.issn.1006-6233.2025.05.021
母婴ABO血型不合引起新生儿溶血病血清学检验结果与孕妇免疫球蛋白G抗体效价的关联性分析
Correlation between Serologic Testing Results and Maternal Immunoglobulin G antibody Titer in Hemolytic Disease of Newborn Induced by ABO Blood Group Incompatibility
摘要
Abstract
Objective:To analyze the correlation between serologic testing results and maternal immuno-globulin G(IgG)antibody titer in hemolytic disease of newborn(HDN)induced by ABO blood group incom-patibility.Methods:A total of 142 children with HDN induced by ABO blood group antigen incompatibility in the hospital were enrolled as the research objects between May 2021 and May 2024.All children underwent blood group and related serology examinations.Results:In the 142 children with HDN induced by ABO blood group antigen incompatibility,positive rates in children with groups A and B were 55.63%and 44.37%,re-spectively.According to serologic testing,positive rates of direct anti-human globulin test,free IgG antibody test and antibody release test were 12.68%,48.59%and 100%,respectively.The titer distribution of IgG anti-A(B)antibody was as follows:1∶64,1∶128,1∶256,1∶592,1∶1024,and the corresponding number of cases was as follows:64 cases(45.07%),37 cases(26.06%),22 cases(15.49%),11 cases(7.75%),8 cases(5.63%).There were significant differences in titer distribution of IgG antibody between mild HDN group and moderate to severe HDN group(P<0.05).Conclusion:The titer of IgG antibody is correla-ted with the severity of HDN.关键词
母婴ABO血型不合/新生儿溶血病/血清学检验/孕妇免疫球蛋白G抗体效价Key words
ABO blood group incompatibility/Hemolytic disease of newborn/Serologic test/Maternal immunoglobulin G antibody titer引用本文复制引用
马玉,杨劲,孙仁俊..母婴ABO血型不合引起新生儿溶血病血清学检验结果与孕妇免疫球蛋白G抗体效价的关联性分析[J].河北医学,2025,31(5):824-827,4.基金项目
2020年度安徽省自然科学基金项目,(编号:2008085QB73) （编号:2008085QB73）
