河北医学2025，Vol.31Issue(5)：843-848,6.DOI:10.3969/j.issn.1006-6233.2025.05.025
心肺复苏成功患者早期发生心血管衰竭的影响因素分析
Influencing Factors for Early Cardiovascular Failure in Patients with Successful Cardiopulmonary Resuscitation
摘要
Abstract
Objective:To analyze the influencing factors of early cardiovascular failure in patients with successful cardiopulmonary resuscitation(CPR).Methods:A total of 132 patients who achieved return of spontaneous circulation(ROSC)after CPR in our hospital from January 2022 to January 2024 were selected.Patients were divided into a cardiovascular failure group(occurred within 72 hours after resuscitation)and a non-cardiovascular failure group(not occurred)based on cardiovascular status changes after resuscitation.Demographic data,medical history,CPR-related parameters,and blood biochemical indices were compared between the two groups.Multivariate logistic regression analysis was used to identify independent risk factors for early cardiovascular failure in successfully resuscitated patients.Results:Among 132 successfully resuscita-ted patients,91 developed early cardiovascular failure,with an incidence of 68.94%.The cardiovascular fail-ure group had significantly older age,higher proportions of hypertension,diabetes,and smoking,longer CPR duration,higher proportion of epinephrine use before defibrillation,and higher levels of blood lactate,brain natriuretic peptide(BNP),and serum creatinine(SCr)after ROSC compared with the non-cardiovascular failure group(all P<0.05).Levels of endothelin-1(ET-1),nitric oxide(NO),and von Willebrand factor(vWF)were also significantly higher in the cardiovascular failure group(P<0.05).Logistic regression analy-sis showed that hypertension,CPR duration,epinephrine use before defibrillation,and ET-1 were independ-ent risk factors for early cardiovascular failure in successfully resuscitated patients(P<0.05).Conclusion:The occurrence of early cardiovascular failure in patients with successful CPR is closely related to hyperten-sion,long duration of resuscitation,use of adrenaline before defibrillation and elevated ET-1 level.Clinical monitoring and management of high-risk patients should be strengthened.关键词
心脏骤停/心肺复苏/成功/心血管衰竭/独立影响因素Key words
Cardiac arrest/Cardiopulmonary resuscitation/Successful/Cardiovascular failure/Independent influencing factor引用本文复制引用
张瑞辰,程艳,颜娇,葛晓,孙春燕..心肺复苏成功患者早期发生心血管衰竭的影响因素分析[J].河北医学,2025,31(5):843-848,6.基金项目
山西省卫生健康委科研课题,(编号:2020161) （编号:2020161）
