中医学报2025，Vol.40Issue(6)：1146-1150,5.DOI:10.16368/j.issn.1674-8999.2025.06.184
基于骨稳态探讨细胞自噬对激素性股骨头坏死的影响
Effect of Autophagy on Hormonal Femoral Head Necrosis Based on Bone Homeostasis
摘要
Abstract
Hormonal femoral head necrosis is an important type of non-traumatic femoral head necrosis,which is mainly caused by the improper use of hormones to cause the destruction of femoral head osteocytes and bone marrow components,resulting in abnormal ex-pression of osteoblasts,osteoclasts and osteocytes,that is,bone homeostasis.Autophagy can regulate the activity of osteoblasts and osteo-clasts and protect osteocytes by recycling the cell's own energy substances and play a role in maintaining bone homeostasis.Autophagy with different levels of activity can have positive or negative regulatory results on bone homeostasis.关键词
激素性股骨头坏死/骨稳态/细胞自噬Key words
hormonal necrosis of the femoral head/bone homeostasis/autophagy分类
医药卫生引用本文复制引用
张沛刚,杨志敏,王波文,张瑾,李文茜,沈彩虹,曹玉举..基于骨稳态探讨细胞自噬对激素性股骨头坏死的影响[J].中医学报,2025,40(6):1146-1150,5.基金项目
2023年河南省自然科学基金面上项目(2323-00421193) （2323-00421193）
2022年河南省中医药科学研究专项课题项目(2022ZY2064) （2022ZY2064）
