中医学报2025，Vol.40Issue(6)：1151-1155,5.DOI:10.16368/j.issn.1674-8999.2025.06.185
从肾主气化探析糖尿病肾脏病自噬
Autophagy Mechanism of Diabetic Kidney Disease Based on Kidney Governing Qi Transformation
摘要
Abstract
Autophagy removes and reutilizes damaged organelles and proteins through the lysosomal degradation pathway,representing a form of programmed cell death for self-metabolism and renewal,which can be involved in various pathogenic mechanisms of diabetic kidney disease(DKD).The concept that the Kidne governing Qi transformation is a high-level summary of renal physiological func-tions.Based on the theory of Kidney governing Qi transformation,this paper proposes that autophagy is an important manifestation of the Kidney governing Qi transformation function.Autophagy degrades damaged organelles and proteins through"self-eating",renewing en-ergy and maintaining normal cell metabolism and homeostasis,which aligns with the traditional Chinese medicine view of the Kidney co-ordinating the mutual cultivation,distribution,and transformation processes of Qi,blood,and body Fluids.Insufficient autophagy in DKD aligns with the mechanism of Kidney Qi deficiency;the accumulation of abnormal proteins and organelles caused by insufficient autoph-agy,along with oxidative stress,inflammation,and fibrosis,reflects the micro-level representation of failure of Kidney governing Qi transformation as well as the internal accumulation of Phlegm,Dampness and toxin.关键词
糖尿病肾脏病/自噬/肾主气化Key words
diabetic nephropathy/autophagy/Kidney governing Qi transformation分类
医药卫生引用本文复制引用
施月,石秀杰,段行宇,柳菁,张昱..从肾主气化探析糖尿病肾脏病自噬[J].中医学报,2025,40(6):1151-1155,5.基金项目
北京市自然科学基金面上项目(7232315) （7232315）
中国中医科学院科技创新工程项目(CI2021A01206) （CI2021A01206）
