中医学报2025，Vol.40Issue(6)：1156-1162,7.DOI:10.16368/j.issn.1674-8999.2025.06.186
基于自噬探讨中药治疗帕金森病的研究进展
Research Progress on Traditional Chinese Medicine Treatment of Parkinson's Disease Based on Autophagy
摘要
Abstract
The abnormal aggregation of α-synuclein(α-syn)and mitochondrial dysfunction are one of the main pathological mecha-nisms of Parkinson's disease(PD).Traditional Chinese medicine can regulate cell autophagy and mitophagy through multiple path-ways,promoting the degradation of α-syn and the clearance of damaged mitochondria,thereby reducing neuronal toxicity and protecting dopaminergic neurons.Current research lacks sufficient clinical evidence and the following future research directions are recommended:First,existing studies mostly focus on cell or animal models,lacking large-scale clinical studies to provide further evidence-based medical support;Scond,the specific pathways of certain traditional Chinese medicines remain to be clarified,and future research could delve into elucidating the mechanisms of traditional Chinese medicine,improving the evidence chain for clinical treatment of PD;Third,based on current research,there may be cases of excessive activation of autophagy in PD.Hence,it is necessary to find a balance point between activation and inhibition.Guided by the traditional Chinese medicine theory of yin-yang balance,future studies could analyze the effects of traditional Chinese medicine on different autophagy pathways or explore the dynamic balance of autophagy based on the synergistic effects of traditional Chinese medicine.关键词
帕金森病/自噬/α-突触核蛋白/线粒体/细胞自噬/线粒体自噬Key words
Parkinson's disease/autophagy/α-synuclein/mitochondria/cellular autophagy/mitochondrial autophagy分类
中医学引用本文复制引用
白绿峰,李雅迪,朱垚羽,王宝亮..基于自噬探讨中药治疗帕金森病的研究进展[J].中医学报,2025,40(6):1156-1162,7.基金项目
王宝亮全国名老中医药专家传承工作室建设项目{国中医药人教函[2022]75号} （）
