中医学报2025，Vol.40Issue(6)：1171-1176,6.DOI:10.16368/j.issn.1674-8999.2025.06.188
基于线粒体能量代谢探讨益气活血法治疗心肌缺血损伤的科学内涵
Scientific Connotation of Yiqi Huoxue Method in Treatment of Myocardial Ischemic Injury Based on Mitochondrial Energy Metabolism
摘要
Abstract
Mitochondria is the main site of myocardial energy metabolism,and the demand for oxygen is large,and a variety of factors will destroy the mitochondrial structure,resulting in rupture of the outer mitochondrial membrane,edema of the matrix,and the decrease in number or increase in number and volume decrease,which will further lead to mitochondrial dysfunction under hypoxic conditions.A vicious cycle of functional limitation and structural impairment leads to myocardial energy failure.Yang Qi and mitochondria have simi-larities in many aspects such as growth and aging,immunity,mitochondria is a microscopic existence of Yang Qi,Yang Qi deficiency is the dysfunction of mitochondria,Qi deficiency for a long time,there are tangible evils,and the accumulation of products of energy metab-olism disorders has the same meaning,it is believed that replenishing Yang Qi is the basis for improving myocardial ischemia.Yiqi Huoxue method in TCM can intervene in the mitochondrial energy metabolism process of myocardium from many aspects,such as energy substrate utilization,mitochondrial structure and function,energy metabolism enzyme and protein activity,and play a role in improving exercise tolerance and quality of life of patients with cardiovascular diseases.关键词
心肌缺血损伤/益气活血法/线粒体/能量代谢Key words
myocardial ischemic injury/Yiqi Huoxue method/mitochondria/energy metabolism分类
医药卫生引用本文复制引用
李默涵,葛昭,刘桐作,周梦雪,任思霖,王贤良..基于线粒体能量代谢探讨益气活血法治疗心肌缺血损伤的科学内涵[J].中医学报,2025,40(6):1171-1176,6.基金项目
国家中医药传承创新团队项目-中医药防治心血管疾病传承创新团队(ZYYCXTD-C-202203) （ZYYCXTD-C-202203）
