中医学报2025，Vol.40Issue(6)：1266-1272,7.DOI:10.16368/j.issn.1674-8999.2025.06.204
中药提取物防治高糖诱导视网膜色素上皮细胞损伤的机制研究进展
Mechanism Research Progress on Protective Effect of TCM Herbal Extracts Treating High Glucose Induced Retinal Pigment Epithelial Cell Injury
摘要
Abstract
The occurrence and development of diabetes retinopathy(DR)is closely related to the retinal pigment epithelium(RPE)in-jury,and high glucose environment can aggravate RPE injury through oxidative stress,inflammatory reaction,cell apoptosis and ferropto-sis.Traditional Chinese herbal medicine extracts such as Huangqi(Astragalus membranaceus),Jianghuang(Curcuma longa),Danshen(Salvia miltiorrhiza),Danggui(Angelica sinensis),Yinxingye(Ginkgo biloba leaf),Shihu(Dendrobium officinale),etc.can protect RPE cells from high glucose damage and improve DR efficacy through mechanisms such as antioxidant,anti-inflammatory,anti-apop-tosis,inhibition of ferroptosis,anti pyroptosis,and promotion of autophagy,with broad application prospects.However,there existing the following issues in modern researches:most traditional Chinese medicine extracts have complex components,and the key active ingredi-ents and their mechanisms of action are not yet clear;there is a lack of in-depth exploration of the protective mechanisms of various traditional Chinese medicine extracts on RPE;Existing research has mostly focused on the antioxidant,anti-inflammatory,and anti-apoptotic mechanisms of traditional Chinese medicine extracts,while there is relatively little research on the regulatory mechanisms of ferroptosis,autophagy,and cell pyroptosis.In the future,it is necessary to further clarify the specific targets and pathways of traditional Chinese medicine extracts in intervening in RPE injury,especially the mechanisms of anti pyroptosis and inhibition of ferroptosis,to make up for the shortcomings of traditional therapies and provide a basis for the development of new traditional Chinese medicine prepa-rations.关键词
糖尿病视网膜病变/中药提取物/炎症/氧化应激/细胞凋亡/血糖/炎症反应/铁死亡/细胞焦亡/细胞自噬Key words
diabetic retinopathy/TCM herbal extracts/inflammation/oxidative stress/apoptosis/blood glucose/inflammatory reaction/ferroptosis/pyroptosis/autophagy分类
医药卫生引用本文复制引用
邹秀淇,郑承红,丁念..中药提取物防治高糖诱导视网膜色素上皮细胞损伤的机制研究进展[J].中医学报,2025,40(6):1266-1272,7.基金项目
湖北省中医药管理局中医药科研项目(ZY2023F053) （ZY2023F053）
武汉市知识创新专项基础研究项目(2022020801010582) （2022020801010582）
