中国实用神经疾病杂志2025，Vol.28Issue(5)：541-546,6.DOI:10.12083/SYSJ.241047
早期僵直型帕金森病脑白质微观结构的变化研究
Microstructure changes of white matter in early akinetic-rigid Parkinson's disease
摘要
Abstract
Objective To investigate the microstructural abnormalities in white matter tracts of early akinetic-rigid Parkinson's disease(AR-PD)patients using diffusion tensor imaging(DTI),aiming to reveal specific patterns of white matter damage in AR-PD.Methods A total of 51 AR-PD patients and 61 healthy controls were included in the study.Tract-based spatial statistics(TBSS)were applied to analyze DTI data.Fractional anisotropy(FA)values were compared between the two groups to assess the changes in white matter microstructure.Results Compared to the healthy controls,early AR-PD patients showed significantly reduced FA values in the bilateral anterior thalamic radiation,corticospinal tracts,superior longitudinal fasciculus,inferior longitudinal fasciculus,and the genu and body of the corpus callosum.These changes were strongly correlated with the Movement Disorder Society-sponsored unified Parkinson's disease rating scale(MDS-UPDRS Ⅲ),Hoehn-Yahr(H-Y)stage,and geriatric depression scale(GDS)scores(P＜0.05).Conclusion Early AR-PD patients exhibit significant microstructural changes in white matter tracts,particularly reduced FA values in the bilateral anterior thalamic radiation,corticospinal tracts,and several other brain regions.These changes are closely associated with motor dysfunction and may also influence disease progression.White matter microstructural changes could serve as potential imaging biomarkers for the early diagnosis of AR-PD,providing scientific evidence for early intervention and treatment.关键词
僵直型帕金森病/神经影像学标志物/弥散张量成像/白质纤维束/各向异性分数/基于纤维束的空间统计Key words
Akinetic-rigid Parkinson's disease/Neuroimaging biomarkers/Diffusion tensor imaging/White matter tracts/Fractional anisotropy/Tract-based spatial statistics分类
医药卫生引用本文复制引用
李鹏宇,申雨,丁凯玥,白岩,魏巍,李寒寒,王梅云..早期僵直型帕金森病脑白质微观结构的变化研究[J].中国实用神经疾病杂志,2025,28(5):541-546,6.基金项目
国家重点研发计划重点专项项目(编号:2023YFC2414200) （编号:2023YFC2414200）
国家自然科学基金面上项目(编号:82371934) （编号:82371934）
河南省医学科技攻关省部共建重大项目(编号:SBGJ202101002) （编号:SBGJ202101002）
河南省科技研发计划联合基金项目(编号:225200810062) （编号:225200810062）
河南省科技攻关计划项目(编号:242102311029) （编号:242102311029）
