中国实用神经疾病杂志2025，Vol.28Issue(5)：552-557,6.DOI:10.12083/SYSJ.241649
伴海马硬化性颞叶癫痫患者皮层及皮层下形态学特征的变化及评价
Changes and evaluation of cortical and subcortical morphological features in temporal lobe epilepsy patients with hippocampal sclerosis
摘要
Abstract
Objective To measure the cortical and subcortical gray matter volume,cortical thickness and cortical surface area in temporal lobe epilepsy with hippocampal sclerosis(TLE-HS)patients,and to analyze the clinical significance of the differences.Methods A total of 101 TLE-HS patients(TLE-HS group)and 220 healthy volunteers(HC group)were enrolled.All subjects underwent MRI examination to obtain high-resolution 3D-T1 MPRAGE structural image data,which were segmented and quantified by Freesurfer software based on Aseg and DKT maps.The morphological parameters were compared between the two groups using the general linear model(GLM)with age,sex,education level and total intracranial volume as covariates.Spearman correlation analysis was used to analyze the correlation between the subcortical nucleus volume with difference and disease duration.Results The volumes of the left pallidum((1 959.48±248.76)mm3)and the right thalamus((7 398.25±1 043.41)mm3)in the TLE-HS group were significantly reduced,while the volumes of the right hippocampus((4 131.69±785.72)mm3),amygdala((1 858.13±360.08)mm3)and the cortical gray matter((237 967.87±36 128.67)mm3)in the right hemisphere were significantly increased(P＜0.05).The abnormal cortical thickness and cortical surface area in the TLE-HS group were mainly manifested in the temporal lobe and frontal lobe.Conclusion The morphological changes of cerebral cortex and subcortical structures in TLE-HS patients provide important imaging evidence for further understanding the pathophysiological mechanism of TLE-HS.关键词
颞叶癫痫/海马硬化/磁共振成像/灰质体积/皮层厚度Key words
Temporal lobe epilepsy/Hippocampal sclerosis/Magnetic resonance imaging/Gray matter volume/Cortical thickness分类
医药卫生引用本文复制引用
闫玲玲,罕迦尔别克·库锟,哈丽玛·马太提,王云玲,贾琳..伴海马硬化性颞叶癫痫患者皮层及皮层下形态学特征的变化及评价[J].中国实用神经疾病杂志,2025,28(5):552-557,6.基金项目
新疆维吾尔自治区科技厅"天山英才"科技创新领军人才项目(编号:2023TSYCLJ0027) （编号:2023TSYCLJ0027）
新疆维吾尔自治区自然科学基金资助项目(编号:2022D01C774) （编号:2022D01C774）
2022年度"青年科研启航"专项基金项目(编号:2022YFY-QKQN-86) （编号:2022YFY-QKQN-86）
