中国实用神经疾病杂志2025，Vol.28Issue(5)：583-587,5.DOI:10.12083/SYSJ.240576
癫痫患者血清miR-130b-3p FGL2及HMGB1的表达临床分析
Clinical analysis of serum miR-130b-3p,FGL2 and HMGB1 expressions in patients with epilepsy
摘要
Abstract
Objective To investigate the expressions of serum miR-130b-3p,fibrinogen-like protein 2(FGL2),and high mobility group box 1 protein(HMGB1)in the patients with epilepsy.Methods Totally 106 epilepsy patients admitted to Zhengdong Hospital of the First Affiliated Hospital of Zhengzhou University between February 2020 and February 2023 were selected as research group.According to 2∶1 ratio,53 healthy volunteers undergoing physical examinations at the same hospital were randomly recruited as control group.Serum levels of miR-130b-3p,FGL2,and HMGB1 were measured in both groups.Patients were subgrouped based on seizure frequency:42 cases with seizures occurring once every two months or less were classified into mild group,while 64 cases with more than one seizure within two months formed moderate-severe group.The expression profiles of miR-130b-3p,FGL2,and HMGB1 were compared between both subgroups.Results The relative expression level of serum miR-130b-3p in the research group(3.56±1.03 vs 1.11±0.23),FGL2 levels[(165.48±11.09)×103 mg/L vs(87.66±12.06)× 103 mg/L],and HMGB1 levels[(371.15±31.25)×103 ng/L vs(281.12±35.98)× 103 ng/L]were all significantly elevated compared to the control group(P＜0.05).Serum miR-130b-3p relative expression(3.11±0.98 vs 3.98±1.12),FGL2 concentrations[(149.26±38.14)×103 mg/L vs(222.16±45.03)×103 mg/L],and HMGB1 levels[(324.56±45.16)× 103 ng/L vs(398.71±39.46)× 103 ng/L]in the mild subgroup were all significantly reduced compared to the moderate-severe subgroup(P＜0.05).Conclusion In the peripheral blood of epilepsy patients,miR-130b-3p,FGL2,and HMGB1 levels are markedly up-regulated,and are concentrations positively correlated with disease severity.These findings suggest their potential as novel biomarkers providing critical biological insights for epilepsy diagnosis and therapeutic development.关键词
癫痫/miR-130b-3p/纤维蛋白原样蛋白2/高迁移率族蛋白B1/血清Key words
Epilepsy/miR-130b-3p/Fibrinogen protein 2/High mobility protein 1/Serum分类
临床医学引用本文复制引用
师云波,崔莹,马耀华,赵婷..癫痫患者血清miR-130b-3p FGL2及HMGB1的表达临床分析[J].中国实用神经疾病杂志,2025,28(5):583-587,5.基金项目
2024年河南省科技攻关计划项目(编号:242102311276) （编号:242102311276）
