四川大学学报（医学版）2025，Vol.56Issue(2)：331-338,8.DOI:10.12182/20250360101
缺氧相关疾病动物模型研究进展
Application of Animal Models in Research on Hypoxia-Related Diseases
摘要
Abstract
Hypoxia-related diseases,such as altitude sickness,acute lung injury,and heart failure,have emerged as significant public health challenges worldwide and are strongly associated with increased mortality risks.These conditions tend to cause functional impairment and structural alterations in multiple organs,primarily due to inadequate oxygen supply or the inability of tissues to utilize oxygen effectively.To elucidate the pathophysiological mechanisms underlying hypoxia-associated diseases and to explore potential therapeutic strategies,researchers have employed animal models to conduct extensive mechanistic studies and drug development trials.In this review,we provide a comprehensive overview of the methods used to construct animal models for various hypoxia-related diseases.We made a thorough evaluation of the strengths,weaknesses,limitations,and applicability of each approach.In particular,we focus on modeling strategies for key pathologies such as altitude sickness,acute lung injury,pulmonary hypertension,and heart failure,discussing their respective advantages and restrains.Furthermore,we examined the potential application of gene editing technologies in optimizing animal models,especially its role in enhancing the accuracy and reproducibility of the models.The integration of these advanced technologies holds great promise for developing animal models with improved specificity and simulation of key features of diseases,which will serve as a solid foundation for basic research,drug screening,and preclinical trials concerning hypoxia-related diseases.Herein,we present a systematic summary and future outlook of animal models for hypoxia-related diseases,ultimately providing theoretical support for developing clinical treatment strategies and improving patient outcomes.关键词
缺氧/动物模型/综述Key words
Hypoxia/Animal models/Review引用本文复制引用
徐一帆,周陈晨,刘希成,郭维华,周建..缺氧相关疾病动物模型研究进展[J].四川大学学报（医学版）,2025,56(2):331-338,8.基金项目
国家自然科学基金(No.81741106、No.82470961、No.82170951、No.82222015、No.82171001),北京市自然科学基金面上项目(No.7222079),首都医科大学硝酸盐维持低氧稳态机制及转化应用基础临床联合实验室,首都医科大学附属北京口腔医院青年科技创新人才培育计划(No.YSP202408)资助 （No.81741106、No.82470961、No.82170951、No.82222015、No.82171001）
