四川大学学报（医学版）2025，Vol.56Issue(2)：339-344,6.DOI:10.12182/20250360103
牙周疾病动物模型复制研究进展
Research Advances in the Replication of Animal Models for Periodontal Diseases
摘要
Abstract
Rodent models play a crucial role in research on human periodontal diseases,providing key evidence for investigation into the pathological mechanisms of periodontal bone defects.Relevant research in the field involves gene expression,inflammatory regulation mechanisms,host-microbial interactions,as well as disease resolution and healing processes.Research methodology in the field falls under 2 categories-periodontal inflammation models and surgical defect models.The former simulates periodontal defects by inducing periodontal diseases,while the latter constructs clinically simulated periodontal defects through surgical removal of periodontal tissue.However,the currently available animal models of periodontitis face challenges in simultaneously capturing the disease complexity,tracking dynamic repair processes,and meeting translational needs.Herein,we reviewed and summarized the methods and characteristics of periodontal disease modeling in recent years.We proposed the establishment of a multimodal assessment framework integrating technologies such as spatial transcriptomics,single-cell sequencing,and in vivo fluorescence imaging,which may serve as a critical pathway for overcoming existing research challenges.关键词
牙周炎/牙槽骨吸收/动物疾病模型Key words
Periodontitis/Alveolar bone loss/Disease models,animal引用本文复制引用
王霏扬,马语卓,吕雪蓉,张可为,王悦,盛佳琦,曹煜,韩香,王晓茜..牙周疾病动物模型复制研究进展[J].四川大学学报（医学版）,2025,56(2):339-344,6.基金项目
国家自然科学基金(No.82101018)、江苏省科教能力提升工程一江苏省研究型医院建设单位(No.YJXYYJSDW4)、口腔疾病防治全国重点实验室开放课题(No.SKLOD2024OF06)和江苏省医学创新中心(No.CXZX202227)资助 （No.82101018）
