四川大学学报（医学版）2025，Vol.56Issue(2)：345-354,10.DOI:10.12182/20250360301
软骨-骨交互作用的病理机制:动物实验研究骨关节炎的新视角
Pathology of Cartilage-to-Bone Crosstalk:A New Angle for Animal Experimental Studies on Osteoarthritis
摘要
Abstract
Osteoarthritis(OA),a common age-related chronic disease,is characterized by degenerative changes in the joints and surrounding tissues.Traditionally,research on OA has primarily focused on the pathological changes in articular cartilage and its repair.However,with the advancements in animal disease modeling in recent years,especially the widespread use of spatiotemporally specific transgenic mouse models,scholars have gradually come to realize that the subchondral bone also plays an important role in the occurrence and development of OA.That is,the pathological changes in articular cartilage and bone mutually affect and promote each other,jointly driving the progression of OA,involving such pathological processes as vascular invasion,ectopic calcification,nerve growth,and the occurrence of pain.Given the complexity of cartilage-bone pathological relationship,it is difficult to conduct in-depth research on subchondral bone pathology using clinical human samples,or to simulate the pathological processes of OA through in vitro cell experiments.Therefore,animal models play an irreplaceable role in investigating the pathological mechanisms of OA and developing clinical drugs.This review,in addition to providing an overview of OA animal models,synthesizes the latest progress in animal experimental research on OA,highlighting the active role of the cartilage-bone pathological relationship in OA progression.These new findings provide references for future in-depth investigations and also provide a theoretical basis for developing fundamental strategies for OA prevention and treatment.关键词
骨关节炎/关节软骨/软骨下骨/动物模型Key words
Osteoarthritis/Articular cartilage/Subchondral bone/Animal models引用本文复制引用
吴嘉宁,周雨萌,刘懿瑾,刘肖珩,张平,张德茂..软骨-骨交互作用的病理机制:动物实验研究骨关节炎的新视角[J].四川大学学报（医学版）,2025,56(2):345-354,10.基金项目
国家自然科学基金(No.82001062、No.11932014),中国博士后科学基金(No.2022M722249)和四川省科技厅重点研发计划项目(No.2022YFS0118)资助 （No.82001062、No.11932014）
