四川大学学报（医学版）2025，Vol.56Issue(2)：355-363,9.DOI:10.12182/20250360504
骨-血管轴共病动物模型研究进展
Advances in Animal Modeling in the Study of Bone-Vascular Axis Comorbidities
摘要
Abstract
Osteoporosis and cardiovascular calcification,two major age-related chronic diseases that China is confronting today,pose serious threats to public health.Previous studies have reported overlapping connections in the pathological processes and molecular mechanisms of these two diseases,particularly concerning inflammation,oxidative stress,and dysregulation of mineral metabolism,and that these two diseases tend to share common pathogenic factors.However,research exploring the comorbidity mechanisms of the two diseases remains limited in both depth and scope,largely due to the lack of widely accepted comorbidity animal models.Herein,we analyzed the latest research findings on the comorbidity mechanisms of vascular calcification and osteoporosis,focusing on summarizing the animal disease models currently in extensive use and the relevant evaluation criteria.We aim to provide new references for comorbidity research models and offer scientific evidence for future studies on pathological mechanisms and the development of new therapeutic strategies.关键词
血管钙化/骨质疏松/动物模型/综述Key words
Vascular calcification/Osteoporosis/Animal models/Review引用本文复制引用
李佳阳,周雨萌,罗钰雯,黄雪琳,张德茂,刘肖珩..骨-血管轴共病动物模型研究进展[J].四川大学学报（医学版）,2025,56(2):355-363,9.基金项目
国家自然科学基金(No.82001062、No.11932014、No.12372315)和中国博士后科学基金(No.2022M722249)资助 （No.82001062、No.11932014、No.12372315）
