四川大学学报（医学版）2025，Vol.56Issue(2)：425-433,9.DOI:10.12182/20250360201
孟德尔随机化探究循环中的免疫细胞与自身免疫性肝炎之间的关系
Exploring the Causal Relationship Between Circulating Immune Cells and Autoimmune Hepatitis Through Mendelian Randomization Analysis
摘要
Abstract
Objective To elucidate the causal relationship between specific immune cells and autoimmune hepatitis(AIH)using a two-sample Mendelian randomization(MR)approach.Methods A bidirectional MR analysis was conducted using data from large publicly accessible Genome-Wide Association Study(GWAS)databases.The inverse variance weighted(IVW)method was employed as the primary method to evaluate the relationship between 731 immune cell traits and AIH.The false discovery rate(FDR)was controlled using the Benjamini-Hochberg correction.Additionally,pleiotropy and heterogeneity tests were performed,and a leave-one-out sensitivity analysis was conducted to further validate the robustness of the results.Results At a significance level of 0.20,it was found that the absolute count of CD28-CD8+regulatory T-cells(IVW:odds ratio[OR]=1.486;95％confidence interval[CI],1.189-1.859;P＜0.001;PFDR=0.185),the level of CD28 on CD39+secreting regulatory T-cells(IVW:OR=1.194;95％CI,1.074-1.328;P=0.001;PFDR=0.185),and the level of CD45 on mononuclear myeloid-derived suppressor cells(IVW:OR=1.243;95％CI,1.108-1.394;P＜0.001;PFDR=0.143)were associated with an increased risk of AIH.The level of programmed death-ligand 1 on CD14+CD16+monocytes(IVW:OR=0.849;95％CI,0.771-0.935;P＜0.001;PFDR=0.185)was associated with a reduced risk of AIH.Conclusion Four immune cell phenotypes associated with AIH risk are identified.Further investigation is needed to validate these findings and explore new therapeutic avenues.关键词
孟德尔随机化/自身免疫性肝炎/免疫细胞Key words
Autoimmune hepatitis/Mendelian randomization/Immune cells引用本文复制引用
冷松,王克芬,石毓君,邓成..孟德尔随机化探究循环中的免疫细胞与自身免疫性肝炎之间的关系[J].四川大学学报（医学版）,2025,56(2):425-433,9.基金项目
国家自然科学基金(No.32270438)和四川大学华西医院国家老年疾病临床医学研究中心(No.Z2023JC003)资助 （No.32270438）
