四川大学学报（医学版）2025，Vol.56Issue(2)：470-477,8.DOI:10.12182/20250360203
生物学衰老可影响中老年群体认知功能的下降速度——基于CHARLS数据的队列研究
Biological Aging Affects the Rate of Cognitive Decline in Middle-aged and Elderly Populations:A Cohort Study Based on CHARLS
摘要
Abstract
Objective To investigate the relationship between biological aging and the rate of cognitive decline in middle-aged and elderly populations.Methods Longitudinal tracking data of cognitive function were obtained from the China Health and Retirement Longitudinal Study(CHARLS).We employed the Klemera and Doubal method(KDM)to estimate biological age(BA),and calculate the biological aging index(BAI)and biological aging type(BAT).A multivariate linear regression model was employed to analyze the relationships between baseline BAI,BAT,and cognitive function scores.Based on the baseline analysis,a mixed-effects model was used to examine the longitudinal associations between baseline BAI,BAT,and cognitive function during follow-up.Results A total of 5 897 participants were included in the study.BAI was found to be negatively associated with baseline cognitive function scores,with the partial regression coefficient(β)(95％CI)being-0.185(—0.231,—0.139)(P＜0.001).Compared with the lagged aging group,the premature aging group had lower cognitive function scores(β[95％CI]:—0.741[—0.966,—0.516]).For age and sex,for each additional year of baseline BAI,cognitive function scores declined by an average of 0.012(95％CI:—0.019,—0.005)points per year after adjusting for age and sex,and declined by 0.011(95％CI:—0.018,—0.004)points per year after adjusting for other covariates.Compared with participants with lagged aging,those with premature aging experienced,on average,an additional decline of 0.042(95％CI:—0.075,0.009)points per year in cognitive function scores after adjusting for age and sex alone,and by 0.039(95％CI:—0.072,—0.007)points per year after adjusting for other covariates.Conclusion Biological aging affects the rate of cognitive decline in middle-aged and elderly populations.A higher BAI is associated with a faster decline in cognitive function.Compared with those with lagged aging,individuals with premature aging exhibit a more rapid rate of cognitive decline.关键词
衰老/生物学年龄/认知功能Key words
Aging/Biological age/Cognitive function引用本文复制引用
贺绘宇,魏孟伶,钟娇,王娟,黄磊,兰亚佳,张洋..生物学衰老可影响中老年群体认知功能的下降速度——基于CHARLS数据的队列研究[J].四川大学学报（医学版）,2025,56(2):470-477,8.基金项目
四川省科技厅四川省自然科学基金(No.2023NSFSC1736)和四川省科技厅重点研发项目(No.2022YFS0422)资助 （No.2023NSFSC1736）
