解放军医学院学报2025，Vol.46Issue(1)：28-36,9.DOI:10.12435/j.issn.2095-5227.24092301
小型猪糖尿病模型的建立、应用及关键技术问题:实践经验及文献回顾
Establishment,applications,and key technical chanllenges of diabetic models in miniature pigs:practical experience and literature review
摘要
Abstract
The prevalence of diabetes mellitus is increasing worldwide,and diabetic complications have become the main causes of end-stage eye disease and end-stage renal disease.Therefore,there is a need for continuous in-depth research on the pathogenesis of diabetes and related complications and the development of newdiagnostic and therapeutic strategies.Animal model is an indispensable means of experimental research.In recent years,diabetic miniature pig model has received extensive attention and is considered as a bridge for the translation of rodent model research results to clinical practice.Based on the research experience of our laboratory,this paper reviews the research advances in the establishment and application of diabetic models in miniature pigs,including:the advantages of miniature pig in diabetes research,type 1 diabetic models of miniature pig,type 2 diabetic models of miniature pig,diabetic models of genetically modified miniature pig,diabetic complications research in miniature pig and technical issues need attentions,so as to assist diabetes researchers to quickly understand the relevant content and provide valuable experience.关键词
小型猪/糖尿病/动物模型/并发症/遗传修饰Key words
minipig/diabetes mellitus/animal model/complications/genetic modification分类
医药卫生引用本文复制引用
陈华..小型猪糖尿病模型的建立、应用及关键技术问题:实践经验及文献回顾[J].解放军医学院学报,2025,46(1):28-36,9.基金项目
国家自然科学基金项目(32370568) （32370568）
