皮肤性病诊疗学杂志2025，Vol.32Issue(5)：315-321,7.DOI:10.3969/j.issn.1674-8468.2025.05.001
氨甲环酸治疗黄褐斑疗效的meta分析
A meta-analysis on the efficacy of tranexamic acid in the treatment of melasma
ALHEJAIRI Rehab 1ALA'ASuwaitDeebAlSu-wait 1陈永锋1
作者信息
- 1. 南方医科大学皮肤病医院,广东 广州 510091
- 折叠
摘要
Abstract
The aim of this study was to compare the efficacy of TXA with other therapies for melasma.Melasma is a common acquired skin condition characterized by hypermelanosis,causing light to dark patches,and is the most prevalent in individuals with Fitzpatrick skin types Ⅲ to Ⅵ.It is a complex condition with an unclear etiology,often influenced by factors such as excessive sun exposure and hormonal changes.Treating melasma poses significant challenges for healthcare providers,primarily due to its tendency to reoccur.This makes management strategies crucial for achieving lasting results and improving patient outcomes.A systematic review of randomized controlled trials(RCTs)was conducted using databases such as MEDLINE,EMBASE,Google Scholar,and Cochrane,yielding 10 studies encompassing 455 participants.The analysis incorporated oral,topical,and injectable forms of TXA,with treatment durations ranging from 8 weeks to 1 year.Pooled re-sults using a random-effects model indicated a moderate effect size of 0.477,suggesting TXA's efficacy in re-ducing melasma severity.However,high heterogeneity(I2=97.62％)reflected variations in study protocols,TXA delivery methods,and patient demographics.关键词
氨甲环酸/黄褐斑/色素沉着过度/黄褐斑面积及严重程度指数Key words
tranexamic acid/melasma/hyperpigmentation/melasma area and severity index引用本文复制引用
ALHEJAIRI Rehab,ALA'ASuwaitDeebAlSu-wait,陈永锋..氨甲环酸治疗黄褐斑疗效的meta分析[J].皮肤性病诊疗学杂志,2025,32(5):315-321,7.
