皮肤性病诊疗学杂志2025，Vol.32Issue(5)：329-334,6.DOI:10.3969/j.issn.1674-8468.2025.05.003
氨甲环酸联合Q开关激光和果酸换肤术治疗稳定期黄褐斑的疗效分析
Analysis of the efficacy of tranexamic acid combined with Q-switched laser and chemical peeling for the treatment of stable melasma
摘要
Abstract
Objective To analyze the efficacy of tranexamic acid(TXA)combined with Q-switched laser and chemical peeling(α hydroxyl acid)for the treatment of stable melasma.Meth-ods A total of 93 patients with stable melasma were recruited and randomly divided into group A(oral TXA+chemical peels)with 31 cases,group B(oral TXA+Q-switched laser)with 32 ca-ses,and group C(oral TXA+Q-switched laser+chemical peeling)with 30 cases.After the treatment,the efficacy was evaluated,and adverse reactions were observed.Results After 12-week treatment,the total effective rate in group C(80.00％)was significantly higher than that in group A(29.03％)and group B(56.25％)(both P＜0.05 vs.group C).Skin lesion color,lesion area,and mMASI scores were lower in group C compared to groups A and B(both P＜0.05 vs.group C).No severe adverse reactions occurred in any patients during the treatment.Conclusion The combination of tranexamic acid,Q-switched laser,and chemical peeling is an effective treatment for stable melasma,with few adverse reactions.关键词
黄褐斑/Q开关激光/果酸换肤/氨甲环酸Key words
melasma/Q-switch laser/chemical peeling/tranexamic acid引用本文复制引用
张青华,黄尾全,张弦,司卫振,钟静..氨甲环酸联合Q开关激光和果酸换肤术治疗稳定期黄褐斑的疗效分析[J].皮肤性病诊疗学杂志,2025,32(5):329-334,6.基金项目
广东省医学科学技术研究基金(A2022083) （A2022083）
