皮肤性病诊疗学杂志2025，Vol.32Issue(5)：335-338,4.DOI:10.3969/j.issn.1674-8468.2025.05.004
35％果酸联合重组人干扰素α-2β乳膏治疗面部扁平疣的疗效观察
Clinical observation on the efficacy of 35％glycolic acid combined with recombinant human interferon alpha-2 β cream for treating facial flat warts
侯晶梅 1杨艳萍 1蒲小霞 1李云凤 1宋洪彬 1杨瑞1
作者信息
- 1. 宁夏回族自治区人民医院宁夏医科大学第三临床医学院,宁夏 银川 750002
- 折叠
摘要
Abstract
Objective To evaluate the efficacy of 35％glycolic acid combined with recombi-nant human interferon α-2β ointment for treating facial flat warts.Methods A total of 71 patients with flat warts who visited the Dermatology Department of Ningxia Hui Autonomous Region People's Hospital from January 2023 to December 2023 were randomized into a treatment group(36 cases)and a control group(35 cases)using a random number table.The treatment group received 35％glycolic acid therapy once every two weeks and topical recombinant human interferon α-2 β oint-ment(four times daily),while the control group received only the interferon ointment(four times daily).Treatment was discontinued upon complete lesion resolution,with a maximum treatment duration of 3 months.After the treatment,the regression of skin lesions,adverse reactions,and recurrence rates were compared between the two groups.Results Thirty-five patients completed the study in each group.The treatment group achieved a total effective rate of 77.14％(27/35,including 2 cured and 25 markedly improved cases),which was significantly higher than that of the control group,42.86％(15/35,1 cured and 14 improved)(x2=8.57,P=0.003).After a 3-month follow-up,the recurrence rate in the treatment group(11.43％)was slightly lower than that in the control group(20.00％),but the difference was not statistically significant(P=0.342).No severe adverse reactions occurred in either group.Conclusion The combination of 35％glycolic acid and recombinant human interferon α-2 β ointment is an effective treatment for facial flat warts,with few adverse reactions.关键词
面部扁平疣/35％果酸/重组人干扰素α-2β乳膏Key words
facial flat warts/35％fruit acid/recombinant human interferon alpha-2βcream引用本文复制引用
侯晶梅,杨艳萍,蒲小霞,李云凤,宋洪彬,杨瑞..35％果酸联合重组人干扰素α-2β乳膏治疗面部扁平疣的疗效观察[J].皮肤性病诊疗学杂志,2025,32(5):335-338,4.
