摘要
Abstract
Rosacea is a chronic inflammatory disease affecting the central face,with approxi-mately 6％to 72％of patients experiencing ocular involvement.Ocular rosacea shares a similar pathogenesis with cutaneous rosacea,involving immune responses,neurovascular dysfunction,and alterations in the ocular microbiome,which contribute to inflammation and meibomian gland dys-function.Common ocular manifestations include conjunctivitis,blepharitis,keratitis,and telangi-ectasia of the lid margin.However,these clinical features are nonspecific making diagnosis chal-lenging,especially blepharokeratoconjunctivitis in children,where the absence of skin symptoms often leads to misdiagnosis or missed diagnosis.Current treatment emphasizes a gradual and step-wise approach,with most management being empirical and symptomatic.Further exploration of ef-fective,targeted treatment options is necessary.This article reviews the pathogenesis,clinical manifestations,diagnosis,and treatment advancements of ocular rosacea to enhance clinicians'un-derstanding of this disease.关键词
眼型玫瑰痤疮/适应性免疫/固有免疫/TLR-4Key words
ocular rosacea/adaptive immune system/innate immune system/TLR-4
