皮肤性病诊疗学杂志2025，Vol.32Issue(5)：377-382,6.DOI:10.3969/j.issn.1674-8468.2025.05.012
妊娠特应性皮疹的诊疗进展
Advances in the diagnosis and treatment of atopic eruption in pregnancy
摘要
Abstract
Atopic eruption of pregnancy(AEP)is the most common inflammatory skin disease during pregnancy,typically presenting with eczematous or pruritic lesions,with onset most frequent-ly occurring in early to mid-pregnancy.AEP significantly impacts patients' quality of life,and its pathogenesis involves Th2 immune dominance during pregnancy,epidermal barrier dysfunction,and genetic susceptibility.Its diagnosis is primarily based on clinical presentation,medical histo-ry,and necessary laboratory tests,requiring differentiation from other pregnancy-related dermato-ses such as pemphigoid gestationis.Treatment emphasizes an individualized approach,with safety as the primary concern.Basic therapy includes topical emollients and low-potency corticosteroids,while phototherapy is appropriate for refractory cases.In systemic treatment,cyclosporine may serve as a first-line immunosuppressant,whereas methotrexate is explicitly contraindicated.In recent years,JAK inhibitors(e.g.,baricitinib)and biologics(e.g.,dupilumab)have shown potential in AEP treatment,though their safety during pregnancy requires further evaluation.Clinical decision-making must balance disease control with fetal safety,and future research should focus on real-world data to optimize treatment strategies.This review summarizes the latest advances in the epidemiolog-ical characteristics,diagnostic criteria,pathogenesis,and therapeutic approaches for AEP.关键词
妊娠特应性皮疹/妊娠/安全性/创新性药物Key words
atopic eruption of pregnancy/pregnancy/safety/innovative drugs引用本文复制引用
刘萍,任世菊,曾奇峰,蔡敏,刁庆春,王禹毅..妊娠特应性皮疹的诊疗进展[J].皮肤性病诊疗学杂志,2025,32(5):377-382,6.基金项目
重庆市皮肤病学临床医学研究中心(CSTC2015yfpt_gcjsyjzx12-14),重庆市教育委员会科学技术研究项目(KJQN202415120) （CSTC2015yfpt_gcjsyjzx12-14）
