国际眼科杂志2025，Vol.25Issue(6)：875-885,11.DOI:10.3980/j.issn.1672-5123.2025.6.02
不同血糖水平白内障患者超声乳化手术参数和眼前节参数的相关性分析
Analysis of phacoemulsification parameters and anterior segment parameters in cataract patients with different blood glucose levels
摘要
Abstract
AIM:To analyze the characteristics and correlation of phacoemulsification parameters and anterior segment parameters in cataract patients with different blood glucose levels. METHODS:A total of 45 type 2 diabetic cataract patients(45 eyes)treated in our hospital from March 2023 to April 2024 were stratified into two groups based on glycosylated hemoglobin(HbA1c)levels:group A:HbA1c＜7％(n=18)and group B:7％≤ HbA1c＜8.5％(n=27);a total of 94 age-matched age-related cataract patients(94 eyes)were enrolled as the control group(group C).All underwent phacoemulsification with intraocular lens implantation.Anterior segment parameters,including corneal,lens and anterior chamber measurements,were recorded.Correlations between phacoemulsification parameters and anterior segment parameters were analyzed,and differences among groups were compared. RESULTS:In groups A and B,effective phacoemulsification time(EPT)negatively correlated with corneal endothelial cell density(CECD)(r=-0.315,P=0.035).Average phacoemulsification time(APT)positively correlated with the anterior corneal surface radius of curvature(Rm;r=0.402,P=0.006)and negatively correlated with the flat axis meridian curvature(K,),steep axis meridian curvature(K2),mean curvature(Km)of the anterior corneal surface,and lens density at 6 mm zones(PDZ3;all P＜0.05).Average phacoemulsification energy(AVE)positively correlated with mean lens density(LD-mean),lens density at 2 mm zones(PDZ1),lens density at 4 mm zones(PDZ2),and PDZ3(all P＜0.05),and negatively with pupil diameter(r=-0.385,P=0.009).In the group C,EPT showed a positive correlation with Pentacam nucleus staging(PNS)density grade,PDZ1,PDZ2,and PDZ3(all P＜0.05).A positive correlation was observed between AVE and PNS classification(r=0.246,P=0.018).Conversely,AVE exhibited a negative correlation with CECD(r=-0.245,P=0.018).EPT in groups A and B was higher than that in the group C(P＜0.05).Both EPT and APT in the group B were higher than those in the group A(P＜0.05).In diabetic cataract patients,CECD,corneal density(CD),and posterior corneal surface height positively correlated with diabetes duration(P＜0.05).Posterior corneal surface K1 and Rm positively correlated with 7％≤ HbA1c＜8.5％(P＜0.05).Total corneal astigmatism negatively correlated with HbA1c,2-hour post-breakfast blood glucose(2hPBG),and fasting insulin(FINS;P＜0.05).CD and lens thickness(LT)positively correlated with FINS(P＜0.05). CONCLUSION:Phacoemulsification parameters and blood glucose-related indices exhibited varying degrees of correlation with anterior segment parameters in cataract patients with different blood glucose levels.EPT in diabetic cataract patients was higher than that in age-related cataract patients,while EPT and APT in diabetic cataract patients with poor glycemic control were higher than those with good glycemic control.关键词
糖尿病性白内障/有效超声乳化时间/平均超声乳化能量/平均超声乳化时间/眼前节参数Key words
diabetic cataract/effective phacoemulsification time/average phacoemulsification energy/average phacoemulsification time/anterior segment parameter引用本文复制引用
徐昕琦,王萍,刘桐,王磊,朱玄生,张慧文,石磊,高雯..不同血糖水平白内障患者超声乳化手术参数和眼前节参数的相关性分析[J].国际眼科杂志,2025,25(6):875-885,11.基金项目
Anhui Provincial Department of Education Key Project(No.2024AH050550) 安徽省教育厅重点项目(No.2024AH050550) （No.2024AH050550）
