国际眼科杂志2025，Vol.25Issue(6)：894-899,6.DOI:10.3980/j.issn.1672-5123.2025.6.04
高度近视患者SMILE术后角膜光密度及高阶像差的变化
Changes of corneal densitometry and higher-order aberrations in high myopia patients after small incision lenticule extraction
摘要
Abstract
AIM:To observe the changes of corneal densitometry(CD)and higher-order aberrations after small incision lenticule extraction(SMILE),and to explore their correlations and influencing factors. METHODS:Prospective study.A total of 62 high-degree myopia and compound myopic astigmatism patients(62 eyes)who underwent SMILE in Urumqi Aier Eye Hospital from December 2022 to November 2023 were collected.The CD,root mean square of corneal higher-order aberrations(RMS HOA),spherical aberration,vertical coma,horizontal coma,and corneal epithelial thickness(CET)of the patients were measured before surgery,and at 1 d,1 wk,1,3,and 6 mo after surgery,respectively. RESULTS:There were 4 patients lost to follow-up during the period,all due to failure to attend scheduled reexaminations.The number of complete and valid cases was 58 eyes.The CD in the central and paracentral regions of the anterior,middle,and total layer of the cornea increased significantly on the first day after surgery(all P＜0.003).At 6 mo after surgery,there was a slight but statistically significant decrease in the CD of the central and paracentral regions of the anterior and the total anterior layer(all P＜0.003).Compared with the preoperative baseline values,the RMS HOA,spherical aberration,and vertical coma significantly increased at 6 mo after surgery(all P＜0.003),while the change in horizontal coma was not statistically significant.Compared with the preoperative baseline values,the CET in the central,paracentral,and peripheral regions of the cornea,as well as the total average CET in the 0-7 mm range of the cornea increased at 6 mo after surgery(all P＜0.003).At 1 d after surgery,CD of the anterior layer and total layer in the central region of the cornea were positively correlated with the CET in the central region(rs=0.327,rs=0.250,all P＜0.05).At 6 mo after the surgery,the CD of the middle layer and posterior layer in the central corneal region were negatively correlated with the preoperative spherical equivalent and the change of RMS HOA(all P＜0.05). CONCLUSION:The anterior CD decreases at 6 mo after SMILE for high myopia correction,and there is a certain correlation between the changes in CD and some clinical parameters.关键词
飞秒激光小切口基质透镜取出术(SMILE)/光密度/角膜高阶像差Key words
small incision lenticule extraction(SMILE)/corneal densitometry/corneal higher-order aberrations引用本文复制引用
张杨婧,马立威,蔡国华,刘苏,王瑞夫,祖丽皮娅..高度近视患者SMILE术后角膜光密度及高阶像差的变化[J].国际眼科杂志,2025,25(6):894-899,6.基金项目
乌鲁木齐市卫生健康委科技计划项目(No.202370) Science and Technology Program of Urumqi Health Commission project(No.202370) （No.202370）
