国际眼科杂志2025，Vol.25Issue(6)：906-911,6.DOI:10.3980/j.issn.1672-5123.2025.6.06
晚期糖基化终末产物在眼部疾病中的作用研究进展
Research progress on the role of advanced glycosylation end products in ocular diseases
摘要
Abstract
The excessive accumulation of advanced glycosylation end products(AGEs),the end products of non-enzymatic glycosylation reactions,can be involved in the pathological processes of various ocular diseases through mechanisms such as oxidative stress,inflammatory responses and apoptosis.In this paper,we systematically reviewed the key role of AGEs in diabetic keratopathy,cataract,glaucoma,age-related macular degeneration(ARMD)and diabetic retinopathy(DR).It was found that AGEs activate signalling pathways such as NADPH oxidase,MAPK and NF-κB by binding to the receptor RAGE,leading to reactive oxygen species(ROS)generation,release of inflammatory factors,and vascular endothelial dysfunction,which in turn induces delayed corneal healing,cross-linking of lens proteins,optic nerve degeneration,formation of choroidal neovascularisation(CNV),and blood-retinal barrier(BRB)disruption.For example,in diabetic keratopathy,AGEs delay wound healing via the ROS/NLRP3 inflammatory vesicle axis;in cataract,ascorbic acid-mediated cross-linking of lens proteins due to AGEs directly impairs lens transparency;and in DR,AGEs exacerbate microvascular damage by regulating vasucular endothelial growth factor(VEGF)expression and pericyte apoptosis.In addition,this article discusses the advances and limitations of AGEs detection techniques,such as the potential application of lens AGEscan fluorescence assay in screening for diabetic complications,and the need to develop tissue-specific assays for aqueous humour and vitreous.For therapeutic strategies,the research directions of inhibiting AGEs production,blocking RAGE signalling pathway and developing anti-glycosylation drugs are proposed to emphasise their clinical value in delaying disease progression.This review not only integrates the molecular mechanisms and clinical associations of AGEs in ocular diseases,but also provides a theoretical basis for targeted interventions,which is of great significance in exploring novel diagnostic and therapeutic strategies.关键词
糖基化终末产物/糖尿病/糖尿病视网膜病变Key words
advanced glycosylation end products/diabetes/diabetic retinopathy引用本文复制引用
龚小琪,冯娇娇,韩毅博,宋继科,毕宏生..晚期糖基化终末产物在眼部疾病中的作用研究进展[J].国际眼科杂志,2025,25(6):906-911,6.基金项目
国家重点研发计划项目(No.2019YFC1710203) （No.2019YFC1710203）
山东省自然科学基金项目(No.ZR2021LZY045) National Key Research and Development Programme of China(No.2019YFC1710203) （No.ZR2021LZY045）
Natural Science Foundation of Shandong Province(No.ZR2021LZY045) （No.ZR2021LZY045）
