中南医学科学杂志2025，Vol.53Issue(3)：418-421,4.DOI:10.15972/j.cnki.43-1509/r.2025.03.009
肥胖型PCOS不孕症患者血清铁代谢指标、miR-29a、VIP的变化及临床意义
Changes and clinical significance of serum iron metabolism indexes,miR-29a and VIP in obese PCOS infertility patients
摘要
Abstract
Aim To investigate the changes and clinical significance of serum iron metabolism indexes,miR-29a and va-soactive intestinal peptide(VIP)in obese polycystic ovary syndrome(PCOS)infertility patients.Methods We selected 130 PCOS infertility patients and divided them into obese and non-obese groups according to BMI.The obese group was further divided into successful ovulation induction pregnancy group and failure group,or poor pregnancy outcome group and favorable outcome group based on follow-up results.Serum ferritin,miR-29a and VIP levels were compared among groups.Receiver operating character-istic(ROC)curve analysis was performed to evaluate the predictive value of ferritin,miR-29a and VIP.Results The obese group showed higher ferritin and miR-29a levels but lower VIP level compared with the non-obese group(P＜0.05).The failure group had higher ferritin and miR-29a levels but lower VIP level compared with the success group(P＜0.05).The poor outcome group demonstrated higher ferritin and miR-29a levels but lower VIP level compared with the favorable outcome group(P＜0.05).Ferritin,miR-29a and VIP showed good predictive value for ovulation induction failure,while ferritin and miR-29a exhibited good predictive value for poor pregnancy outcomes(P＜0.05).Conclusion Serum ferritin and miR-29a levels increase while VIP level decreases in PCOS infertility patients,which significantly associate with ovulation induction pregnancy and pregnancy out-comes.关键词
肥胖型PCOS/不孕症/铁蛋白/miR-29a/VIP/妊娠结局Key words
obese PCOS/infertility/ferritin/miR-29a/VIP/pregnancy outcome分类
临床医学引用本文复制引用
王屹雯,任宝红,周亚红,温丽娜..肥胖型PCOS不孕症患者血清铁代谢指标、miR-29a、VIP的变化及临床意义[J].中南医学科学杂志,2025,53(3):418-421,4.基金项目
江苏省中医药科技发展计划项目(YB2020043) （YB2020043）
